Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
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Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Nils Homer,Nils Homer,Szabolcs Szelinger,Margot Redman,David Duggan,Waibhav Tembe,Jill Muehling,John V. Pearson,Dietrich A. Stephan,Stanley F. Nelson,David Craig +10 more
TL;DR: High-density single nucleotide polymorphism genotyping microarrays are used to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture, and suggest future research efforts into assessing the viability of previously sub-optimal DNA sources due to sample contamination.
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Jasmonate passes muster: a receptor and targets for the defense hormone.
TL;DR: The oxylipin jasmonate (JA) regulates many aspects of growth, development, and environmental responses in plants, particularly defense responses against herbivores and necrotrophic pathogens as mentioned in this paper.
Journal ArticleDOI
Genetics and genomics of core short tandem repeat loci used in human identity testing.
TL;DR: The physical location of each STR locus in the human genome is delineated and allele ranges and variants observed in human populations are summarized as are mutation rates observed from parentage testing.
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Improving human forensics through advances in genetics, genomics and molecular biology
Manfred Kayser,Peter de Knijff +1 more
TL;DR: Advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future, including new molecular approaches for finding individuals previously unknown to investigators, and new molecular methods to support links between forensic sample donors and criminal acts.
Journal ArticleDOI
Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application.
TL;DR: This review examines the advances in paper-based microfluidic diagnostics for medical diagnosis in the context of global health from 2007 to 2016 and highlights emerging health applications, such as male fertility testing and wearable diagnostics.
References
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Journal ArticleDOI
Large-scale comparative genotyping and kinship analysis: evolution in its use for human identification in mass fatality incidents and missing persons databasing
TL;DR: This presentation will review the evolution of a bioinformatic tool originally created to assist with the identification of the victims of the Swissair Air Disaster in 1998, which was re-built in 2001 to handle the much more demanding complexities of the WTC tragedy.
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Death in bathtub revisited with molecular genetics: a victim with suicidal traits and a LQTS gene mutation.
TL;DR: Post-mortem (PM) DNA analysis disclosed KCNH2(FIN) mutation for the long-QT syndrome (LQTS), and the value of PM molecular screening for LQTS is emphasised, especially for victims of putative drowning.
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The UK National DNA Database.
TL;DR: In March this year it was announced that for the first time in the UK the police will have the right to retain indefinitely the DNA profiles from all people from whom DNA is collected, whether the person is charged with a crime or not.
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Novel method of DNA extraction from bones assisted DNA identification of World Trade Center victims
TL;DR: Modifications and improvements to procedures used to extract DNA from bone fragments found at the site of the 11 September 2001 WTC attack are described.