Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
Citations
More filters
Journal ArticleDOI
An overview on forensic analysis devoted to analytical chemists.
TL;DR: The present article has as main aim to show analytical chemists interested in forensic analysis the world they will face if decision in favor of being a forensic analytical chemist is adopted.
Journal ArticleDOI
Increasing the discrimination power of forensic STR testing by employing high-performance mass spectrometry, as illustrated in indigenous South African and Central Asian populations
Florian Pitterl,Konrad Schmidt,Gabriela Huber,Bettina Zimmermann,Rhena Delport,Sylvain Amory,Sylvain Amory,Sylvain Amory,Bertrand Ludes,Herbert Oberacher,Walther Parson +10 more
TL;DR: An alternative approach that makes use of nucleotide variation within the amplified STR fragments, which can be discerned by mass spectrometry is pursued, which determines molecular masses from crude STR amplicons which were purified and separated by a liquid chromatographic system directly hyphenated to an electrospray ionization mass spectromaeter.
Journal ArticleDOI
Dna testing in animal forensics
TL;DR: How the use of nonhuman DNA testing is beginning to find a place in the prosecution of individuals is discussed, which requires rigorous validation of precision and accuracy, allele heritability and independence, accurate sampling, evidence handling, and appropriate statistical evaluation of the results.
Journal ArticleDOI
Genetic diversities and phylogenetic analyses of three Chinese main ethnic groups in southwest China: A Y-Chromosomal STR study.
Pengyu Chen,Guanglin He,Xing Zou,Xin Zhang,Jida Li,Zhisong Wang,Hongyan Gao,Li Luo,Zhongqing Zhang,Jian Yu,Yanyan Han +10 more
TL;DR: Collectively, this new-generation Y-STR amplification system can be used as a supplementary tool in forensic identification and male parentage testing and even pedigree search.
References
More filters
Journal ArticleDOI
Hypervariable 'minisatellite' regions in human DNA.
TL;DR: A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
Book ChapterDOI
The Apportionment of Human Diversity
TL;DR: Lewontin this article pointed out that even in the present era of Darwinism there is considerable diversity of opinion about the amount or importance of intragroup variation as opposed to the variation between races and species.
Journal ArticleDOI
Individual-specific 'fingerprints' of human DNA.
TL;DR: It is shown that other variant (core)n probes can detect additional sets of hypervariable minisatellites to produce somatically stable DNA ‘fingerprints’ which are completely specific to an individual (or to his or her identical twin) and can be applied directly to problems of human identification, including parenthood testing.