Journal ArticleDOI
Encoded evidence: DNA in forensic analysis
Mark A. Jobling,Peter Gill +1 more
TLDR
For example, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases as mentioned in this paper.Abstract:
Sherlock Holmes said "it has long been an axiom of mine that the little things are infinitely the most important", but never imagined that such a little thing, the DNA molecule, could become perhaps the most powerful single tool in the multifaceted fight against crime. Twenty years after the development of DNA fingerprinting, forensic DNA analysis is key to the conviction or exoneration of suspects and the identification of victims of crimes, accidents and disasters, driving the development of innovative methods in molecular genetics, statistics and the use of massive intelligence databases.read more
Citations
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Journal ArticleDOI
Infrared Laser Heating Applied to Nanopore Sensing for DNA Duplex Analysis
TL;DR: The use of IR-based direct absorption heating with the DNA sensing capabilities of a biological nanopore is demonstrated and it is demonstrated that the IR heating enables one to measure the percentage of different-sized DNA molecules in a binary mixture.
Journal ArticleDOI
The National DNA Data Bank of Canada: a Quebecer perspective.
TL;DR: Some of the current use of the database, its potential for the future, and opportunity to expand as a result of recent technological developments in molecular biology, including, but not limited to DNA identification are highlighted.
Book
Post-Conviction DNA Testing and Wrongful Conviction
John K. Roman,Kelly A. Walsh +1 more
TL;DR: To provide better customer service, NCJRS has made this Federally-funded grant final report available online in addition to traditional paper copies as discussed by the authors, which is the first time that NC JRS has done so.
BookDOI
Microfluidic methods for molecular biology
Chang Lu,Scott S. Verbridge +1 more
TL;DR: This book covers the state-of-the-art research on molecular biology assays and molecular techniques enabled or enhanced by microfluidic platforms and reviews exhaustively the latest techniques for single-cell genetic, epigenetic, metabolomic, and proteomic analysis.
Journal ArticleDOI
A fully integrated microchip system for automated forensic short tandem repeat analysis
TL;DR: An integrated microsystem that combines two plastic microchips for DNA extraction and PCR amplification with a glass capillary array electrophoresis chip together in a compact control and detection instrument for automated forensic short tandem repeat (STR) analysis is developed.
References
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Journal ArticleDOI
Hypervariable 'minisatellite' regions in human DNA.
TL;DR: A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
Book ChapterDOI
The Apportionment of Human Diversity
TL;DR: Lewontin this article pointed out that even in the present era of Darwinism there is considerable diversity of opinion about the amount or importance of intragroup variation as opposed to the variation between races and species.
Journal ArticleDOI
Individual-specific 'fingerprints' of human DNA.
TL;DR: It is shown that other variant (core)n probes can detect additional sets of hypervariable minisatellites to produce somatically stable DNA ‘fingerprints’ which are completely specific to an individual (or to his or her identical twin) and can be applied directly to problems of human identification, including parenthood testing.