Journal ArticleDOI
Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells.
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TLDR
Aberrant activation of EGFRs may lead to an overexpression and activation of Met, which may be of importance for the malignant phenotype of anaplastic thyroid carcinomas.About:
This article is published in Experimental Cell Research.The article was published on 2000-08-25. It has received 105 citations till now. The article focuses on the topics: Thyroid carcinoma & Epidermal growth factor.read more
Citations
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Journal ArticleDOI
Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers.
TL;DR: A comprehensive meta-review of thyroid cancer biomarkers revealed well known thyroid cancer markers such as MET, TFF3, SERPINA1, TIMP1, FN1, and TPO as well as relatively novel or uncharacterized genes such as TGFA, QPCT, CRABP1, FCGBP, EPS8 and PROS1 that should help develop a panel of markers with sufficient sensitivity and specificity for the diagnosis of thyroid tumors in a clinical setting.
Journal ArticleDOI
Cancer therapy: can the challenge be MET?
TL;DR: Interfering with Met activation is a new and challenging approach to hamper tumorigenic and metastatic processes.
Journal ArticleDOI
The MET receptor tyrosine kinase in invasion and metastasis
TL;DR: Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or extracellular matrix).
Patent
c-Met modulators and methods of use
Lynne Canne Bannen,Diva Sze-Ming Chan,Jeff Chen,Lisa Esther Dalrymple,Timothy Patrick Forsyth,Tai Phat Huynh,Vasu Jammalamadaka,Richard George Khoury,James W. Leahy,Morrisson B. Mac,Grace Mann,Larry W. Mann,John M. Nuss,Jason Jevious Parks,Craig Stacy Takeuchi,Yong Wang,Wie Xu +16 more
TL;DR: In this article, the authors provide compounds for modifying protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion.
Journal ArticleDOI
Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors
Rama Pai,Rama Pai,Toshikazu Nakamura,Toshikazu Nakamura,Toshikazu Nakamura,Woo S. Moon,Woo S. Moon,Andrzej S. Tarnawski,Andrzej S. Tarnawski +8 more
TL;DR: Evidence is provided that PGE2 transactivates c‐Met‐R (contingent upon functional EGFR), increases tyrosine phosphorylation and nuclear accumulation of β‐catenin, and induces urokinase‐type plasminogen activator receptor (uPAR) mRNA expression, which explains a functional relationship between prostaglandins, EGFR, and c‐ Met‐R in colon cancer growth and invasion.
References
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Journal ArticleDOI
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
Charles Auffray,François Rougeon +1 more
TL;DR: A procedure is described for the large-scale purification of light (L) and heavy (H) chain mRNAs from plasmacytomas produced in mice by oligo(dT)-cellulose chromatography and either sucrose gradient centrifugation in conditions preventing aggregation or by means of high-resolution preparative gel electrophoresis under non-denaturing conditions.
Journal ArticleDOI
Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene
TL;DR: Comparison of these two cDNA sequences with those of the chicken, Drosophila and yeast genes allows the analysis of the evolution of the GAPDH genes in detail.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Laura S. Schmidt,Fuh Mei Duh,F. Chen,Takeshi Kishida,Gladys Glenn,Peter L. Choyke,Stephen W. Scherer,Zhengping Zhuang,Irina A. Lubensky,Michael Dean,Rando Allikmets,Abirami Chidambaram,Ulf S.R. Bergerheim,J. T. Feltis,C. Casadevall,A. Zamarron,M. Bernues,Stéphane Richard,C. J. M. Lips,McClellan M. Walther,Lap-Chee Tsui,Laura Geil,Mary Lou Orcutt,Thomas Stackhouse,J. Lipan,L. Slife,Hiltrud Brauch,Jochen Decker,G. Niehans,M. D. Hughson,Holger Moch,Stefan Storkel,Michael I. Lerman,W.M. Linehan,B. Zbar +34 more
TL;DR: The results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas.
Journal ArticleDOI
Growth factors and cancer
TL;DR: Signaling pathways that mediate the normal functions of growth factors are commonly subverted in cancer, and oncogenes appear to replace the actions of one set of these growth factors.
Related Papers (5)
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,Christopher-Michael Gale,Xiaojun Zhao,James J. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne +18 more