Journal ArticleDOI
Expanding the repertoire of L-DOPA’s actions: A comprehensive review of its functional neurochemistry
TLDR
L-DOPA exerts a surprisingly complex pattern of neurochemical effects of much greater scope that mere striatal transformation into DA in spared dopaminergic neurons, and may exert intrinsic receptor-mediated actions independently of DA neurotransmission and can be processed into bioactive metabolites.About:
This article is published in Progress in Neurobiology.The article was published on 2017-04-01. It has received 92 citations till now. The article focuses on the topics: Substantia nigra & Pars compacta.read more
Citations
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Parkinson's Disease: Biomarkers, Treatment, and Risk Factors.
TL;DR: This review covers molecules that might act as the biomarkers of Parkinson's disease and suggests that microRNA-based analysis may bring considerable progress, especially if it is combined with α-syn data.
Journal ArticleDOI
Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models.
Jia Liu,Weijin Liu,Yongquan Lu,Hao Tian,Chunli Duan,Lingling Lu,Ge Gao,Xia Wu,Xiaomin Wang,Hui Yang +9 more
TL;DR: It is demonstrated that PLG exerts therapeutic effects in a rotenone-induced PD models by restoring the balance between apoptosis and autophagy.
Journal ArticleDOI
Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time
TL;DR: The application of scRNA-seq in the discovery of targets and biomarkers as a new approach in developing novel therapeutics for the treatment of neurodegenerative diseases is advocated.
Journal ArticleDOI
Targeting the norepinephrinergic system in Parkinson's disease and related disorders : The locus coeruleus story
TL;DR: All relevant neurochemical research, including the intriguing link with (prodromal) dementia, several biomarker opportunities, the latest therapeutic strategies to enhance NE signaling, and, finally, some overarching comments and perspectives for future research are discussed.
Journal ArticleDOI
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota.
Yan Wang,Qian Tong,Shu-Rong Ma,Zhen-Xiong Zhao,Li-Bin Pan,Lin Cong,Pei Han,Ran Peng,Hang Yu,Yuan Lin,Tian-Le Gao,Jia-Wen Shou,Xiao-Yang Li,Xian-Feng Zhang,Zheng-Wei Zhang,Jie Fu,Bao-Ying Wen,Jin-Bo Yu,Xuetao Cao,Jian-Dong Jiang +19 more
TL;DR: In this paper, the authors showed that BBR might improve brain function by upregulating the biosynthesis of L-dopa in the gut microbiota through a vitamin-like effect.
References
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Journal ArticleDOI
The functional anatomy of basal ganglia disorders.
TL;DR: A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control.
Journal ArticleDOI
Parkinson's disease: Mechanisms and models
TL;DR: PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
Journal ArticleDOI
Primate models of movement disorders of basal ganglia origin
TL;DR: This paper describes the changes in neuronal activity in the motor circuit in animal models of hypo- and hyperkinetic disorders and postulates specific disturbances within the basal ganglia-thalamocortical 'motor' circuit.
Journal ArticleDOI
A review of central 5-HT receptors and their function
Nicholas M. Barnes,Trevor Sharp +1 more
TL;DR: A number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction and the functional responses attributed to each receptor in the brain are reviewed.
Journal ArticleDOI
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
Charles R. Gerfen,Thomas M. Engber,Lawrence C. Mahan,Zvi Susel,Thomas N. Chase,Frederick J. Monsma,David R. Sibley +6 more
TL;DR: The differential effects of dopamine on striatonigral and striatopallidal neurons are mediated by their specific expression of D1 and D2 dopamine receptor subtypes, respectively.
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