Journal ArticleDOI
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis.
Reads0
Chats0
TLDR
In this paper, the authors discuss the overall role of extracellular vesicles (EVs) in response to various external and internal signals in cancer, and highlight the biogenesis, secretion, and content of EVs in response of oncogenic transformation and metabolic regulators in cancer.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2021-10-07. It has received 4 citations till now. The article focuses on the topics: Exposome & Exposome.read more
Citations
More filters
Journal ArticleDOI
Advances in Purification, Modification, and Application of Extracellular Vesicles for Novel Clinical Treatments
Yasunari Matsuzaka,Ryu Yashiro +1 more
TL;DR: Extracellular Vesicles (EV) are membrane vesicles surrounded by a lipid bilayer membrane and include microvesicles, apoptotic bodies, exosomes, and exomeres as mentioned in this paper .
Journal ArticleDOI
Tissue Nanotransfection Causes Tumor Regression by its Effect on Nanovesicle Cargo that Alters Microenvironmental Macrophage State.
Gayle M. Gordillo,Poornachander R. Guda,Kanhaiya Singh,Ayandip Biswas,Ahmed S. Abouhashem,Yashika Rustagi,Abhishek Sen,Manishekhar Kumar,Amitava Das,Subhadip Ghatak,Savita Khanna,Chandan K. Sen,Sashwati Roy +12 more
TL;DR: In this paper , the authors reported the first nanoscale fluorescent visualization of tumor-originating vesicles bearing an angiogenic microRNA (miR)-126 cargo.
Journal ArticleDOI
Microparticle Phosphatidylserine Mediates Coagulation: Involvement in Tumor Progression and Metastasis
TL;DR: In this paper , the authors provide promising cancer treatment strategies targeting the phosphatidylserine-mediated coagulation cascade and fill current knowledge gaps and investigate the therapeutic potential of coagulated factor inhibitors within the context of cancer treatment.
References
More filters
Journal ArticleDOI
Complementing the Genome with an “Exposome”: The Outstanding Challenge of Environmental Exposure Measurement in Molecular Epidemiology
TL;DR: The sequencing and mapping of the human genome provides a foundation for the elucidation of gene expression and protein function, and the identification of the biochemical pathways implicated in the natural history of chronic diseases.
Journal ArticleDOI
Classification, Functions, and Clinical Relevance of Extracellular Vesicles
TL;DR: Evidence is accumulating that vesicles are cargo containers used by eukaryotic cells to exchange biomolecules as transmembrane receptors and genetic information, and they have a myriad of potential clinical applications, ranging from biomarkers to anticancer therapy.
Journal ArticleDOI
Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis
Laura M. Doyle,Michael Zhuo Wang +1 more
TL;DR: The purpose of this review is to not only introduce the different types of extracellular vesicles but also to summarize their differences and similarities, and discuss different methods of exosome isolation and analysis currently used.
Journal ArticleDOI
Exosomes: biogenesis, biologic function and clinical potential
TL;DR: The potential use of exosomes as valuable diagnostic and prognostic biomarkers for their cell-lineage and state-specific contents, and possibilities as therapeutic vehicles for drug and gene delivery are focused on.
Journal ArticleDOI
Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair
TL;DR: This review deals with UV-induced alterations in DNA and its maintenance by various repair mechanisms that are operative in various organisms with the expense of specific gene products.
Related Papers (5)
Extracellular vesicles in toxicological studies: key roles in communication between environmental stress and adverse outcomes.
Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more