Journal ArticleDOI
Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis.
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TLDR
In this paper, the authors discuss the overall role of extracellular vesicles (EVs) in response to various external and internal signals in cancer, and highlight the biogenesis, secretion, and content of EVs in response of oncogenic transformation and metabolic regulators in cancer.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2021-10-07. It has received 4 citations till now. The article focuses on the topics: Exposome & Exposome.read more
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Advances in Purification, Modification, and Application of Extracellular Vesicles for Novel Clinical Treatments
Yasunari Matsuzaka,Ryu Yashiro +1 more
TL;DR: Extracellular Vesicles (EV) are membrane vesicles surrounded by a lipid bilayer membrane and include microvesicles, apoptotic bodies, exosomes, and exomeres as mentioned in this paper .
Journal ArticleDOI
Tissue Nanotransfection Causes Tumor Regression by its Effect on Nanovesicle Cargo that Alters Microenvironmental Macrophage State.
Gayle M. Gordillo,Poornachander R. Guda,Kanhaiya Singh,Ayandip Biswas,Ahmed S. Abouhashem,Yashika Rustagi,Abhishek Sen,Manishekhar Kumar,Amitava Das,Subhadip Ghatak,Savita Khanna,Chandan K. Sen,Sashwati Roy +12 more
TL;DR: In this paper , the authors reported the first nanoscale fluorescent visualization of tumor-originating vesicles bearing an angiogenic microRNA (miR)-126 cargo.
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Microparticle Phosphatidylserine Mediates Coagulation: Involvement in Tumor Progression and Metastasis
TL;DR: In this paper , the authors provide promising cancer treatment strategies targeting the phosphatidylserine-mediated coagulation cascade and fill current knowledge gaps and investigate the therapeutic potential of coagulated factor inhibitors within the context of cancer treatment.
References
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Journal ArticleDOI
Lung cancer exosomes as drivers of epithelial mesenchymal transition
Mohammad Alinoor Rahman,Jennifer F. Barger,Francesca Lovat,Min Gao,Gregory A. Otterson,Patrick Nana-Sinkam +5 more
TL;DR: The results suggest that cancer derived exosomes could be a potential mediator of EMT in the recipient cells, as well as induce migration, invasion and proliferation in non-cancerous recipient cells.
Journal ArticleDOI
Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation.
Lisa Mutschelknaus,Carsten Peters,Klaudia Winkler,Ramesh Yentrapalli,Theresa Heider,Michael J. Atkinson,Simone Moertl +6 more
TL;DR: A functional role of exosome in the response of tumor cells to radiation exposure within a therapeutic dose range is indicated and encourages that exosomes are useful objects of study for a better understanding of tumor radiation response.
Journal ArticleDOI
Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma.
Chenyu Ding,Xuehan Yi,Xiyue Wu,Xingyao Bu,Desheng Wang,Zanyi Wu,Gaoqi Zhang,Jianjun Gu,Dezhi Kang +8 more
TL;DR: It is suggested that exosome-mediated transfer of CircNFIX enhances TMZ resistance in glioma at least partially through sponging miR-132, highlighting a potentially prognostic biomarker and therapeutic target for improving the clinical benefits of TMZ treatment in patients with gliomas.
Journal ArticleDOI
Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis
Haiou Yang,Haiyang Zhang,Yuchong Yang,Xinyi Wang,Ting Deng,Rui Liu,Tao Ning,Ming Bai,Hongli Li,Kegan Zhu,Jialu Li,Qian Fan,Guoguang Ying,Yi Ba +13 more
TL;DR: Hypoxia-derived exosomal circ-133 transported into normaxic cancer cells and promoted cell migration via miR-133a/GEF-H1/RhoA axis and is expected to be a new biomarker for monitoring tumor progression and might be a novel therapeutic target.
Journal ArticleDOI
Bioactive DNA from extracellular vesicles and particles.
TL;DR: The effectiveness of cell-free DNA as the biomarker of choice in emerging liquid biopsy applications highlights the role that EV/EP DNA may play as a novel disease biomarker, and a particular focus on the roles of EV/ EP DNA as a functional mediator and molecular biomarker in various pathologic states.
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