Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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TLDR
The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
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Dissertation
Conception et caracterisation de biocapteurs bases sur l'association de recepteurs et canaux ioniques
TL;DR: In this paper, les canaux sensibles a l'ATP (KATP) result from l'association unique d'une proteine ABC (le recepteur des sulfonylurees, SUR) and d'un canal potassique rectifiant entrant (Kir6.2.x).
Journal ArticleDOI
Deletion of Robo4 prevents high-fat diet-induced adipose artery and systemic metabolic dysfunction.
Tam T. T. Phuong,Ashley E. Walker,Grant D. Henson,Daniel R. Machin,Dean Y. Li,Anthony J. Donato,Lisa A. Lesniewski +6 more
TL;DR: The role of Robo4 in modulating cardiometabolic function in response to high‐fat feeding was determined and it was found that Robo4 is expressed specifically in endothelial cells and increases vascular stability and inhibits angiogenesis.
DissertationDOI
Subversion of Rho GTPases by WxxxE effectors of attaching and effacing pathogens
TL;DR: This chapter introduces the WxxxE Family of Effectors, a large number of which have never been studied before, and discusses their role in the development of E.coli and its pathogenicity.
Journal ArticleDOI
GPCRs that Rhoar the Guanine nucleotide exchange factors.
TL;DR: G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors that are involved in many signalling phenomena, including cell survival and cell migration events.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
Related Papers (5)
The structure and function of G-protein-coupled receptors
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more