Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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TLDR
The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
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GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Gαq-p63RhoGEF-Rho GTPase pathway.
Xiaolong Tang,Rongrong Jin,Guojun Qu,Xiu Wang,Zhenxi Li,Zengjin Yuan,Chen Zhao,Stefan Siwko,Tieliu Shi,Ping Wang,Jianru Xiao,Mingyao Liu,Jian Luo +12 more
TL;DR: Findings show that GPR 116 is crucial for the metastasis of breast cancer and support GPR116 as a potential prognostic marker and drug target against metastatic human breast cancer.
Journal ArticleDOI
Exosomes derived from human macrophages suppress endothelial cell migration by controlling integrin trafficking
TL;DR: Exosomes released from human macrophages negatively regulate endothelial cell migration through control of integrin trafficking and were shown to effectively suppress collagen‐induced activation of the mitogen‐activated protein kinase/extracellular signal‐regulated kinase signaling pathway and HUVEC migration, which are both dependent on integrin β1.
Journal ArticleDOI
Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity.
Maarten B. Kok,Sjoerd Hak,Willem J. M. Mulder,Daisy W. J. van der Schaft,Gustav J. Strijkers,Klaas Nicolay +5 more
TL;DR: This study showed that ανβ3 targeting dramatically increased the uptake of paramagnetic liposomes, however, this targeting strategy strongly influenced both the longitudinal and transverse relaxivity of the internalized paramagneticliposomes.
Journal ArticleDOI
Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin β1 Recycling.
TL;DR: Mechanistically, acid-induced epithelial MV miR-17/221 promoted β1 integrin recycling and presentation back onto the surface of macrophages, in part via a Rab11-mediated pathway, which modulates macrophage β1 Integrin β1 is known to play an essential role in regulatingmacrophage migration.
Journal ArticleDOI
The Membrane‐Associated Protein, Supervillin, Accelerates F‐Actin‐Dependent Rapid Integrin Recycling and Cell Motility
Zhiyou Fang,Norio Takizawa,Korey A. Wilson,Tara C. Smith,Anna Delprato,Anna Delprato,Michael W. Davidson,David G. Lambright,Elizabeth J. Luna +8 more
TL;DR: It is shown that supervillin can localize with markers for early and sorting endosomes (EE/SE) and with overexpressed components of the Arf6 recycling pathway in the cell periphery and enhances signaling from the epidermal growth factor receptor (EGFR) to extracellular signal‐regulated kinases (ERKs) 1 and 2 and increases the velocity of cell translocation.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
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