Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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TLDR
The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
Citations
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ARP2/3 complex is required for directional migration of neural stem cell-derived oligodendrocyte precursors in electric fields
TL;DR: EF-guided cell migration is an effective model to understanding the intracellular signaling pathway in the regulation of cell migration directness and motility and can be controlled by EFs.
Journal ArticleDOI
Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
Caroline Coombs,Antonios Georgantzoglou,Hazel A. Walker,Julian Patt,Nicole Merten,Hugo Poplimont,Elisabeth M. Busch-Nentwich,Sarah Williams,Christina Kotsi,Evi Kostenis,Milka Sarris +10 more
TL;DR: In this paper, differential ligand-induced trafficking of chemokine receptors (Cxcr1 and Cxcr2) orchestrates the state of neutrophil congregation at sites of tissue damage.
Journal ArticleDOI
Protons and Ca2+: ionic allies in tumor progression?
TL;DR: A role for proton-sensing ion channels and GPCRs as mediators of the effects of extracellular protons in cancer cells is discussed.
Journal ArticleDOI
HIF-1α links β-adrenoceptor agonists and pancreatic cancer cells under normoxic condition
Heng Tong Hu,Qing Yong Ma,Dong Zhang,Su Gang Shen,Liang Han,Ya Dong Ma,Ruo Fei Li,Keping Xie +7 more
TL;DR: A novel mechanism in pancreatic cancer cells that links β-AR and HIF-1α signaling under normoxic conditions is suggested, with implications for the control of glucose transport, angiogenesis and metastasis.
Journal ArticleDOI
G Protein-Coupled Receptor 87 (GPR87) Promotes the Growth and Metastasis of CD133+ Cancer Stem-Like Cells in Hepatocellular Carcinoma
Mingxia Yan,Hong Li,Miaoxin Zhu,Fangyu Zhao,Lixing Zhang,Taoyang Chen,Guoping Jiang,Haiyang Xie,Ying Cui,Ming Yao,Jinjun Li +10 more
TL;DR: It is demonstrated that the overexpression of GPR87 up-regulated CD133 expression, promoted CSC-associated migratory and invasive properties in vitro, and increased tumor initiation in vivo.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more