Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
Citations
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Gi-Coupled GPCR Signaling Controls the Formation and Organization of Human Pluripotent Colonies
TL;DR: Experiments with pertussis toxin suggest that Gi signaling plays a critical role in the morphology and organization of pluripotent colonies, and may be explained by a Gi-mediated density-sensing mechanism that propels the cells radially outward.
Journal ArticleDOI
Golgi-associated microtubules are fast cargo tracks and required for persistent cell migration.
Huiwen Hao,Jiahao Niu,Boxin Xue,Qian Peter Su,Menghan Liu,Junsheng Yang,Jinshan Qin,Shujuan Zhao,Congying Wu,Yujie Sun +9 more
TL;DR: The role of Golgi MTs is unveiled in serving as a group of “fast tracks” for anterograde trafficking of post‐Golgi cargos and is demonstrated to be essential for persistent cell migration but not for cells to change direction.
Journal ArticleDOI
Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis.
Susanta Pahari,Gurpreet Kaur,Shikha Negi,Mohammad Aqdas,Deepjyoti K. Das,Hilal Bashir,Sanpreet Singh,Mukta Nagare,Junaid Khan,Javed N. Agrewala +9 more
TL;DR: The strategies to bolster the function of MPS by exploiting the molecules associated with the innate immunity are discussed and the mechanisms involved to overcome the Mtb-induced suppression of host immunity are highlighted.
Journal ArticleDOI
G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation
Kalyan C. Tirupula,Sujay Subbayya Ithychanda,Maradumane L. Mohan,Sathyamangla V. Naga Prasad,Jun Qin,Sadashiva S. Karnik +5 more
TL;DR: It is proposed that the GPCR-induced filamin phosphorylation pathway is a conserved, novel biochemical signaling paradigm, and the data suggest a molecular mechanism for direct G PCR–cytoskeleton coupling via filamin.
Journal ArticleDOI
G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis
TL;DR: GPCRs–AC–cAMP signal pathways involve in the inflammatory and immune response of RA, and the potential therapeutic targets and strategies to modulate GPCRs signaling pathway are new development trends.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more