Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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TLDR
The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
Citations
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Cell Migration Is Regulated by Platelet-Derived Growth Factor Receptor Endocytosis
Kenji Kawada,Geeta Upadhyay,Sébastien Ferandon,Sailajah Janarthanan,Matthew N. Hall,Jean-Pierre Vilardaga,Jean-Pierre Vilardaga,Vijay Yajnik +7 more
TL;DR: It is found that Grb2 serves as an adaptor protein in the formation of a ternary complex between the PDGF receptor, DOCK4, and Dynamin, which is formed at the leading edge of cells and regulates PDGF-dependent cell migration.
Journal ArticleDOI
CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation
TL;DR: The focus of this study was to determine the dedicator of cytokinesis 2 (DOCK2), extracellular signal‐regulated kinase 1/2 (ERK1/2), c‐Jun N‐terminal kinase‐1 (JNK) and Akt signals involved in CXCL13‐mediated prostate cancer (PCa) cell invasion and proliferation.
Journal ArticleDOI
Neuronal action on the developing blood vessel pattern.
TL;DR: How the nervous system directly influences blood vessel patterning resulting in neuro-vascular congruence that is maintained throughout development and in the adult is discussed.
Journal ArticleDOI
Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis.
Beatrice Duthey,Anita Hübner,Sandra Diehl,Sandra Boehncke,Jeannette Pfeffer,Wolf-Henning Boehncke +5 more
TL;DR: Anti‐inflammatory effects of the GABAB receptor agonist baclofen in allergic contact dermatitis is reported to be anti-inflammatory.
Journal ArticleDOI
β-arrestin-dependent actin reorganization: bringing the right players together at the leading edge.
Jungah Min,Kathryn DeFea +1 more
TL;DR: Recent advances in understanding of how β-arrestin scaffolds contribute to cell migration are discussed, focusing on recently identified β-Arrestin interacting proteins and phosphorylation targets that have known roles in actin reorganization.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more