Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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TLDR
The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
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Dissertation
Characterisation of G protein-coupled receptor 56-signalling and its potential role in tumour progression
TL;DR: A novel signalling pathway activated by GPR56 in response to TG2 that is involved in cell proliferation, growth and migration is presented, potentially providing an explanation for the supposed tumour promoting functions of G PR56 in glioblastoma.
Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.
Caroline Coombs,Antonios Georgantzoglou,Hazel A. Walker,Julian Patt,Nicole Merten,Hugo Poplimont,Elisabeth M. Busch-Nentwich,Sarah Williams,Christina Kotsi,Evi Kostenis,Milka Sarris +10 more
TL;DR: In this article, differential ligand-induced trafficking of chemokine receptors (Cxcr1 and Cxcr2) orchestrates the state of neutrophil congregation at sites of tissue damage.
DissertationDOI
Protein interaction partners of ASAP1 and their role in metastasis
TL;DR: The role of ASAP1 in promoting both cell motility and receptor internalization in the context of tumor cells, important biological processes that regulate metastasis formation is demonstrated.
Journal ArticleDOI
Establishing and functional characterization of an HEK-293 cell line expressing autofluorescently tagged β-actin (pEYFP-ACTIN) and the neurokinin type 1 receptor (NK1-R)
TL;DR: These experiments demonstrated that: i) both constructs expressed in the generated transfected cell line are functional; ii) the estimated pEYFP-actin: endogenous β- actin ratio is within the limits required for the functional integrity of the actin filaments; and iii) pEY FP-act in and rhodamine-phalloidine-stained F-actIn structures colocalize and display comparable reorganization patterns in pharmacologically challenged cells.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
Related Papers (5)
The structure and function of G-protein-coupled receptors
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more