Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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TLDR
The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
Citations
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Journal ArticleDOI
Linking actin dynamics and gene transcription to drive cellular motile functions.
Eric N. Olson,Alfred Nordheim +1 more
TL;DR: The discovery that globular actin polymerization liberates myocardin-related transcription factor (MRTF) cofactors induces the nuclear transcription factor serum response factor (SRF) to modulate the expression of genes encoding structural and regulatory effectors of actin dynamics stimulated research to better understand the actin–MRTF–SRF circuit.
Journal ArticleDOI
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration.
Andrea Palamidessi,Emanuela Frittoli,Massimiliano Garrè,Mario Faretta,Marina Mione,Ilaria Testa,Alberto Diaspro,Letizia Lanzetti,Giorgio Scita,Pier Paolo Di Fiore +9 more
TL;DR: It is demonstrated that a Rab5-to-Rac circuitry controls the morphology of motile mammalian tumor cells and primordial germinal cells during zebrafish development, suggesting that this circuitry is relevant for the regulation of migratory programs in various cells, in both in vitro settings and whole organisms.
Journal ArticleDOI
The chemistry, physiology and pathology of pH in cancer
TL;DR: Elevated metabolism, weakened cell-to-capillary diffusive coupling, and adaptations involving H+/H+-equivalent transporters and extracellular-facing CAs give cancer cells the means to manipulate micro-environmental acidity, a cancer hallmark.
Journal ArticleDOI
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.
Shigeyki Nada,Akihiro Hondo,Atsuko Kasai,Masato Koike,Kazunobu Saito,Yasuo Uchiyama,Masato Okada +6 more
TL;DR: Results indicate that the lipid raft adaptor p18 is essential for anchoring the MEK–ERK pathway to late endosomes, and shed new light on a role of endosomal MEK- ERK pathway in controlling endosome dynamics.
Journal ArticleDOI
Three-dimensional context regulation of metastasis
TL;DR: Synergistic interactions between matrix remodeling and tumor hypoxia influence common mechanisms that maximize tumor progression and cooperate to drive metastasis, which should identify novel therapeutic targets.
References
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Journal ArticleDOI
Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase.
TL;DR: A novel role for the ARF6 GTPase is supported in modeling the plasma membrane and underlying cytoskeleton and the formation of protrusive structures was blocked by cytochalasin D and inhibitors of the lipoxygenase pathway.
Journal ArticleDOI
Asymmetric focal adhesion disassembly in motile cells.
TL;DR: A model is presented that suggests two stages of microtubule-driven adhesion disassembly: destabilization and detachment of the adhesion turnover and disassembly in various regions of the cell.
Journal ArticleDOI
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics
Markus Schober,Srikala Raghavan,Maria Nikolova,Lisa Polak,H. Amalia Pasolli,Hilary E. Beggs,Louis F. Reichardt,Elaine Fuchs +7 more
TL;DR: By conditionally ablating Fak in skin epidermis and culturing Fak-null keratinocytes, it is shown that FAK is dispensable for epidermal adhesion and basement membrane assembly, both of which require αβ1 integrins.
Journal ArticleDOI
Evolution of the mammalian G protein α subunit multigene family
Thomas M. Wilkie,Debra J. Gilbert,Anne S. Olsen,Xiao-Ning Chen,Thomas T. Amatruda,Julie R. Korenberg,Barbara J. Trask,Pieter J. de Jong,Randall R. Reed,Melvin I. Simon,Nancy A. Jenkins,Neal G. Copeland +11 more
TL;DR: The murine chromosomal locations of all 15 Gα subunit genes are determined using an interspecific backcross derived from crosses of C57BI/6J and Mus spretus mice to provide insight into the events responsible for generating the genetic diversity found in the mammalian α subunits.
Journal ArticleDOI
Role of β-arrestin 1 in the metastatic progression of colorectal cancer
F. Gregory Buchanan,D. Lee Gorden,Pranathi Matta,Qiong Shi,Lynn M. Matrisian,Raymond N. DuBois +5 more
TL;DR: The results show that the prostaglandin E/β-arrestin 1/c-Src signaling complex is a crucial step in PGE2-mediated transactivation of the EGFR and may play a pivotal role in tumor metastasis.
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