Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
Citations
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Journal ArticleDOI
Visualization of ligand-induced G i -protein activation in chemotaxing cells.
TL;DR: A Förster resonance energy transfer probe is developed, R10‐Gi, by linking the Gi‐protein α subunit to the regulator of G‐protein signaling domain to clarify the mechanisms underlying the subcellular regulation of Gi‐ protein activity, as well as GPCR‐mediated ligand sensing, during chemotaxis in mammalian cells.
Dissertation
Control of cAMP signalling in the cellular migration of pancreatic ductal adenocarcinoma
TL;DR: The aim of this study was to investigate events such as cell ruffling and focal adhesion assembly, which are processes closely associated with cellular motility in PDAC and the effect of cAMP, and its effectors, on the rate of migration.
Combining building thermal simulation methods and LCA methods
TL;DR: In this paper, the authors describe recent efforts made by the Danish Building Research Institute regarding the integration of a life cycle assessment (LCA) method into a whole building hygro-thermal simulation tool.
Journal ArticleDOI
Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts.
Lara-Jane Kepser,Sharof Khudayberdiev,Laura Soto Hinojosa,Chiara Macchi,Massimiliano Ruscica,Elena Marcello,Carsten Culmsee,Robert Grosse,Marco B. Rust,Marco B. Rust +9 more
TL;DR: In this article, cyclase-associated proteins (CAPs) were shown to be important regulators of actin dynamics that control assembly and disassembly of Factin filaments (F-actin).
Posted ContentDOI
Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts
Lara-Jane Kepser,Laura Soto Hinojosa,Chiara Macchi,Massimiliano Ruscica,Elena Marcello,Carsten Culmsee,Carsten Culmsee,Robert Grosse,Marco B. Rust,Marco B. Rust +9 more
TL;DR: Mouse embryonic fibroblasts from CAP2 mutant mice are exploited to deciphering the CAP2-dependent mechanism relevant for SRF activity and it is revealed that in MEFs CAP2 controls basal MRTF-A localization andSRF activity, while it was dispensable for serum-induced nuclear MRTF/SRF translocation and SRF stimulation.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Rho GTPases in cell biology.
TL;DR: Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells and their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
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The structure and function of G-protein-coupled receptors
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more