Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
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TLDR
The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
Citations
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Journal ArticleDOI
Linking actin dynamics and gene transcription to drive cellular motile functions.
Eric N. Olson,Alfred Nordheim +1 more
TL;DR: The discovery that globular actin polymerization liberates myocardin-related transcription factor (MRTF) cofactors induces the nuclear transcription factor serum response factor (SRF) to modulate the expression of genes encoding structural and regulatory effectors of actin dynamics stimulated research to better understand the actin–MRTF–SRF circuit.
Journal ArticleDOI
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration.
Andrea Palamidessi,Emanuela Frittoli,Massimiliano Garrè,Mario Faretta,Marina Mione,Ilaria Testa,Alberto Diaspro,Letizia Lanzetti,Giorgio Scita,Pier Paolo Di Fiore +9 more
TL;DR: It is demonstrated that a Rab5-to-Rac circuitry controls the morphology of motile mammalian tumor cells and primordial germinal cells during zebrafish development, suggesting that this circuitry is relevant for the regulation of migratory programs in various cells, in both in vitro settings and whole organisms.
Journal ArticleDOI
The chemistry, physiology and pathology of pH in cancer
TL;DR: Elevated metabolism, weakened cell-to-capillary diffusive coupling, and adaptations involving H+/H+-equivalent transporters and extracellular-facing CAs give cancer cells the means to manipulate micro-environmental acidity, a cancer hallmark.
Journal ArticleDOI
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.
Shigeyki Nada,Akihiro Hondo,Atsuko Kasai,Masato Koike,Kazunobu Saito,Yasuo Uchiyama,Masato Okada +6 more
TL;DR: Results indicate that the lipid raft adaptor p18 is essential for anchoring the MEK–ERK pathway to late endosomes, and shed new light on a role of endosomal MEK- ERK pathway in controlling endosome dynamics.
Journal ArticleDOI
Three-dimensional context regulation of metastasis
TL;DR: Synergistic interactions between matrix remodeling and tumor hypoxia influence common mechanisms that maximize tumor progression and cooperate to drive metastasis, which should identify novel therapeutic targets.
References
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Journal ArticleDOI
Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways
Peter J. M. Noble,Geraint J. C. Wilde,Michael R. H. White,Steven R. Pennington,Graham J. Dockray,Andrea Varro +5 more
TL;DR: It is concluded that gastrin-CCK(B) receptors stimulate epithelial cell migration partly via paracrine mechanisms; transactivation of EGF-R is only one component of theParacrine pathway.
Journal ArticleDOI
Cooperation of Gq, Gi, and G12/13 in Protein Kinase D Activation and Phosphorylation Induced by Lysophosphatidic Acid
TL;DR: It is proposed that PKD activation is a point of convergence in the action of multiple G-protein pathways and requires additional G- protein pathways to elicit a maximal response with Gi playing a critical role in Gα12/13 KO cells.
Journal ArticleDOI
Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class IA and IB phosphoinositide 3-kinases.
TL;DR: It is demonstrated that optimal chemotactic response of leukemic T cells to SDF-1 requires the activation of both class IA and class IB PI 3-kinases.
Journal ArticleDOI
Inhibition of Gαi2 Activation by Gαi3 in CXCR3-mediated Signaling
Brian Thompson,Y.-J. Jin,Kevin H. Wu,Richard A. Colvin,Andrew D. Luster,Lutz Birnbaumer,Mei X. Wu +6 more
TL;DR: In this article, the authors showed that G alpha(i2) was indispensable for T cell responses to three CXCR3 ligands, CXCL9, CxCL10, and CXCl11, as the lack of G alpha (i2)-protein activation was associated with increased incorporation of guanosine 5'-3-O-(thio)triphosphate (GTPgammaS).
Journal ArticleDOI
Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
Kang Jin Jeong,Soon Young Park,Ji Hye Seo,Kyung Bok Lee,Wahn Soo Choi,Jeung Whan Han,Jaeku Kang,Chang Gyo Park,Yong Kee Kim,Hoi Young Lee +9 more
TL;DR: The results clearly show the significance of LPA2 and Gi/Src pathway for LPA-induced COX-2 expression and cell migration that could be a promising drug target for ovarian cancer cell metastasis.
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