Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
Reads0
Chats0
TLDR
The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.About:
This article is published in Cellular Signalling.The article was published on 2009-07-01. It has received 238 citations till now. The article focuses on the topics: Actin remodeling & Actin cytoskeleton.read more
Citations
More filters
Journal ArticleDOI
Linking actin dynamics and gene transcription to drive cellular motile functions.
Eric N. Olson,Alfred Nordheim +1 more
TL;DR: The discovery that globular actin polymerization liberates myocardin-related transcription factor (MRTF) cofactors induces the nuclear transcription factor serum response factor (SRF) to modulate the expression of genes encoding structural and regulatory effectors of actin dynamics stimulated research to better understand the actin–MRTF–SRF circuit.
Journal ArticleDOI
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration.
Andrea Palamidessi,Emanuela Frittoli,Massimiliano Garrè,Mario Faretta,Marina Mione,Ilaria Testa,Alberto Diaspro,Letizia Lanzetti,Giorgio Scita,Pier Paolo Di Fiore +9 more
TL;DR: It is demonstrated that a Rab5-to-Rac circuitry controls the morphology of motile mammalian tumor cells and primordial germinal cells during zebrafish development, suggesting that this circuitry is relevant for the regulation of migratory programs in various cells, in both in vitro settings and whole organisms.
Journal ArticleDOI
The chemistry, physiology and pathology of pH in cancer
TL;DR: Elevated metabolism, weakened cell-to-capillary diffusive coupling, and adaptations involving H+/H+-equivalent transporters and extracellular-facing CAs give cancer cells the means to manipulate micro-environmental acidity, a cancer hallmark.
Journal ArticleDOI
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.
Shigeyki Nada,Akihiro Hondo,Atsuko Kasai,Masato Koike,Kazunobu Saito,Yasuo Uchiyama,Masato Okada +6 more
TL;DR: Results indicate that the lipid raft adaptor p18 is essential for anchoring the MEK–ERK pathway to late endosomes, and shed new light on a role of endosomal MEK- ERK pathway in controlling endosome dynamics.
Journal ArticleDOI
Three-dimensional context regulation of metastasis
TL;DR: Synergistic interactions between matrix remodeling and tumor hypoxia influence common mechanisms that maximize tumor progression and cooperate to drive metastasis, which should identify novel therapeutic targets.
References
More filters
Journal ArticleDOI
The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho
TL;DR: Data indicate that in Swiss 3T3 cells, G13 but not G12 is involved in the LPA-induced activation of Rho, and results suggest an involvement of the EGF receptor in this pathway.
Journal ArticleDOI
Epidermal Growth Factor Activates m-Calpain (Calpain II), at Least in Part, by Extracellular Signal-Regulated Kinase-Mediated Phosphorylation
Angela Glading,Richard J. Bodnar,Ian J. Reynolds,Hidenori Shiraha,Latha Satish,David Potter,Harry C. Blair,Harry C. Blair,Alan Wells,Alan Wells +9 more
TL;DR: Evidence is provided that m-calpain can be activated through the ERK cascade via direct phosphorylation and that this activation may occur in the absence of cytosolic calcium fluxes.
Journal ArticleDOI
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways
C. Tarricone,Bing Xiao,Neil Justin,Philip A. Walker,Katrin Rittinger,Steven J. Gamblin,Stephen J. Smerdon +6 more
TL;DR: Structures of Arfaptin with Rac bound to either GDP or the slowly hydrolysable analogue GMPPNP show that the switch regions adopt similar conformations in both complexes, and suggest a model of ArFaptin-mediated synergy between the Arf and Rho family signalling pathways.
Journal ArticleDOI
Characterization of RAC3, a novel member of the Rho family
TL;DR: RAC3 protein levels are not affected by organization of the actin cytoskeleton but remarkably, are serum-inducible and support a role for Rac3 in intracellular signaling.
Journal ArticleDOI
A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.
TL;DR: It is reported that expression of the GTPase‐defective mutant of ARF6, ARf6(Q67L), remodels the actin cytoskeleton by inducing actin polymerization at the cell periphery, and a role for POR1 as an important regulatory element in orchestrating cytoskeletal rearrangements at thecell periphery induced by ARF 6 and Rac1 is suggested.
Related Papers (5)
The structure and function of G-protein-coupled receptors
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more