Journal ArticleDOI
Genetics of susceptibility to human infectious disease
Graham S Cooke,Adrian V. S. Hill +1 more
TLDR
Developments in genetics have allowed a more systematic study of the impact that the human genome and infectious disease have on each other, and have confirmed heritability of susceptibility to several infectious diseases.Abstract:
Before Robert Koch's work in the late nineteenth century, diseases such as tuberculosis and leprosy were widely believed to be inherited disorders. Heritability of susceptibility to several infectious diseases has been confirmed by studies in the twentieth century. Infectious diseases, old and new, continue to be an important cause of mortality worldwide. A greater understanding of disease processes is needed if more effective therapies and more useful vaccines are to be produced. As part of this effort, developments in genetics have allowed a more systematic study of the impact that the human genome and infectious disease have on each other.read more
Citations
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Journal ArticleDOI
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Photini Kiepiela,Alasdair Leslie,Isobella Honeyborne,Danni Ramduth,Christina F. Thobakgale,Senica Chetty,Prinisha Rathnavalu,Corey Moore,Katja Pfafferott,Louise Hilton,Peter Zimbwa,Sarah Moore,Todd M. Allen,Christian Brander,Marylyn M. Addo,Marcus Altfeld,Ian James,Simon Mallal,Michael Bunce,Linda Barber,James J. Szinger,James J. Szinger,Cheryl L. Day,Paul Klenerman,James I. Mullins,Bette T. Korber,Bette T. Korber,Hoosen M. Coovadia,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +32 more
TL;DR: Analysis of class I restricted CD8+ T-cell responses against human immunodeficiency virus (HIV-1) indicates that the principal focus of HIV-specific activity is at the HLA-B locus, consistent with the observation that B alleles evolve more rapidly than A alleles.
Journal ArticleDOI
The Influence of HLA Genotype on AIDS
TL;DR: The HLA associations with progression to AIDS that have been consistently affirmed are reviewed and the underlying mechanisms behind some of these associations are discussed based on functional studies of immune cell recognition.
Journal ArticleDOI
Who puts the tubercle in tuberculosis
TL;DR: This Review explores how Mycobacterium tuberculosis influences granuloma formation and maintenance, and ensures the spread of the disease.
Journal ArticleDOI
A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease
Thomas R. Hawn,Annelies Verbon,Annelies Verbon,Kamilla D. Lettinga,Lue Ping Zhao,Shuying Sue Li,Richard J. Laws,Shawn J. Skerrett,Bruce Beutler,Lea Schroeder,Alex Nachman,Adrian Ozinsky,Kelly D. Smith,Kelly D. Smith,Alan Aderem +14 more
TL;DR: This article showed that a common stop codon polymorphism in the ligand-binding domain of TLR5 (TLR5392STOP) is associated with susceptibility to pneumonia caused by Legionella pneumophila.
Journal ArticleDOI
Leukemia in twins: lessons in natural history.
TL;DR: Analysis of twin leukemias reveals a frequent prenatal origin and an early or initiating role for chromosome translocations and provides evidence for a variable and often protracted latency and the need, in childhood acute lymphoblastic leukemia (ALL)/acute myeloblasticukemia (AML), for further postnatal exposures and/or genetic events to produce clinical disease.
References
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Journal ArticleDOI
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more
TL;DR: It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.
Journal ArticleDOI
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Yasunori Ogura,Denise K. Bonen,Naohiro Inohara,Dan L. Nicolae,Felicia F. Chen,Richard Ramos,Heidi M. Britton,Thomas M. Moran,Reda Karaliuskas,Richard H. Duerr,Jean-Paul Achkar,Steven R. Brant,Theodore M. Bayless,Barbara S. Kirschner,Stephen B. Hanauer,Gabriel Núñez,Judy H. Cho +16 more
TL;DR: It is shown that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease, and a link between an innate immune response to bacterial components and development of disease is suggested.
Journal ArticleDOI
Toll-like receptors: critical proteins linking innate and acquired immunity.
TL;DR: Evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses.
Book
Immunobiology: The Immune System in Health and Disease
TL;DR: Introductory immunology textbook for medical students, advanced undergraduates, and graduate students.