Journal ArticleDOI
Gut Microbiota and Epilepsy: A Systematic Review on Their Relationship and Possible Therapeutics
Alina Arulsamy,Qian Ying Tan,Vinod Balasubramaniam,Terence J. O'Brien,Terence J. O'Brien,Mohd Farooq Shaikh,Mohd Farooq Shaikh,Mohd Farooq Shaikh +7 more
TLDR
These limited studies conclusively suggest that gut microbiota diversity and dysbiosis may be involved in the pathology of epilepsy.Abstract:
Dysbiosis of gut microbiota may lead to a range of diseases including neurological disorders. Thus, it is hypothesized that regulation of the intestinal microbiota may prevent or treat epilepsy. The purpose of this systematic review is to evaluate the evidence investigating the relationship between gut microbiota and epilepsy and possible interventions. A systematic review of the literature was done on four databases (PubMed, Scopus, EMBASE, and Web of Science). Study selection was restricted to original research articles while following the PRISMA guidelines. Six studies were selected. These studies cohesively support the interaction between gut microbiota and epileptic seizures. Gut microbiota analysis identified increases in Firmicutes, Proteobacteria, Verrucomicrobia, and Fusobacteria with decreases in Bacteroidetes and Actinobacteria in epileptic patients. Ketogenic diet, probiotics, and fecal microbiota transplantation (FMT) improved the dysbiosis of the gut microbiota and seizure activity. However, the studies either had a small sample size, lack of subject variability, or short study or follow-up period, which may question their reliability. Nevertheless, these limited studies conclusively suggest that gut microbiota diversity and dysbiosis may be involved in the pathology of epilepsy. Future studies providing more reliable and in depth insight into the gut microbial community will spark promising alternative therapies to current epilepsy treatment.read more
Citations
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Journal ArticleDOI
The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders.
Katarzyna Socała,Urszula Doboszewska,Aleksandra Szopa,Anna Serefko,Marcin Włodarczyk,Anna Zielińska,Ewa Poleszak,Jakub Fichna,Piotr Wlaź +8 more
TL;DR: This review summarizes recent data on the role of microbiota-gut-brain axis in the pathophysiology of neuropsychiatric and neurological disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy.
Journal ArticleDOI
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
TL;DR: The human body is full of an extensive number of commensal microbes, consisting of bacteria, viruses, and fungi collectively termed the human microbiome as discussed by the authors , and the initial acquisition of microbiota occurs from both the external and maternal environments.
Journal ArticleDOI
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Shokufeh Ghasemian Sorboni,Hanieh Shakeri Moghaddam,Reza Jafarzadeh-Esfehani,Saman Soleimanpour +3 more
TL;DR: This review aims to present a comprehensive overview of the potential involvement of the human gut microbiome in the pathogenesis of neurological disorders, with a particular emphasis on the potential of microbe-based therapies and/or diagnostic microbial biomarkers.
Journal ArticleDOI
Probiotics and gut microbiome - Prospects and challenges in remediating heavy metal toxicity.
K.B. Arun,Aravind Madhavan,Raveendran Sindhu,Shibitha Emmanual,Parameswaran Binod,Arivalagan Pugazhendhi,Ranjna Sirohi,R. Reshmy,Mukesh Kumar Awasthi,Edgard Gnansounou,Ashok Pandey +10 more
TL;DR: In this paper, a review summarizes the effect of heavy metals in altering the gut microbiome, the mechanism by which gut microbiota detoxifies heavy metals, diseases developed due to heavy metal-induced dysbiosis of the Gut microbiome, and the usage of probiotics along with advancements in developing improved recombinant probiotic strains for the remediation of heavy metal toxicity.
Journal ArticleDOI
Gut Microbiota Interaction with the Central Nervous System throughout Life.
TL;DR: In this article, the authors summarized selected findings of the recent literature concerning the gut microbiome on the onset and progression of neurodevelopmental and degenerative disorders, and the strategies to modulate its composition in the search for therapeutical approaches, focusing mainly on animal models studies.
References
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Journal ArticleDOI
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement
David Moher,Larissa Shamseer,Mike Clarke,Davina Ghersi,Alessandro Liberati,Mark Petticrew,Paul G. Shekelle,Lesley A. Stewart +7 more
TL;DR: A reporting guideline is described, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015), which consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review.
Ítems de referencia para publicar Protocolos de Revisiones Sistemáticas y Metaanálisis: Declaración PRISMA-P 2015 Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement
David Moher,Larissa Shamseer,Michael Clarke,Davina Ghersi,Alessandro Liberati,Mark Petticrew,Lesley A. Stewart +6 more
Journal ArticleDOI
Enterotypes of the human gut microbiome
Manimozhiyan Arumugam,Jeroen Raes,Eric Pelletier,Denis Le Paslier,Takuji Yamada,Daniel R. Mende,Gabriel Fernandes,Julien Tap,Thomas Brüls,Jean-Michel Batto,Marcelo Bertalan,Natalia Borruel,Francesc Casellas,Leyden Fernández,Laurent Gautier,Torben Hansen,Masahira Hattori,Tetsuya Hayashi,Michiel Kleerebezem,Ken Kurokawa,Marion Leclerc,Florence Levenez,Chaysavanh Manichanh,H. Bjørn Nielsen,Trine Nielsen,Nicolas Pons,Julie Poulain,Junjie Qin,Thomas Sicheritz-Pontén,Sebastian Tims,David Torrents,Edgardo Ugarte,Erwin G. Zoetendal,Jun Wang,Francisco Guarner,Oluf Pedersen,Willem M. de Vos,Søren Brunak,Joël Doré,Jean Weissenbach,S. Dusko Ehrlich,Peer Bork +41 more
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
Journal ArticleDOI
The gut microbiota shapes intestinal immune responses during health and disease
TL;DR: Findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut are discussed, and the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms is raised.
Journal ArticleDOI
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
Els van Nood,A. Vrieze,Max Nieuwdorp,Susana Fuentes,Erwin G. Zoetendal,Willem M. de Vos,Caroline E. Visser,Ed J. Kuijper,Peter Speelman,Josbert J. Keller +9 more
TL;DR: The infusion of donor feces was significantly more effective for the treatment of recurrent C. difficile infection than the use of vancomycin and patients showed increased fecal bacterial diversity, similar to that in healthy donors, with an increase in Bacteroidetes species and clostridium clusters IV and XIVa and a decrease in Proteobacteria species.