Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential: Results From the Women's Health Initiative.
Bernhard Haring,Alexander P. Reiner,Jingmin Liu,Deirdre K Tobias,Deirdre K Tobias,Eric A. Whitsel,Jeffrey S. Berger,Pinkal Desai,Sylvia Wassertheil-Smoller,Michael J. LaMonte,Kathleen M. Hayden,Alexander G. Bick,Pradeep Natarajan,Joshua S. Weinstock,Patricia K. Nguyen,Marcia L. Stefanick,Michael S. Simon,Charles B. Eaton,Charles Kooperberg,JoAnn E. Manson +19 more
TLDR
The presence of clonal hematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of atherosclerotic cardiovascular disease, cancer, and mortality as discussed by the authors.Abstract:
Background Presence of clonal hematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of atherosclerotic cardiovascular disease, cancer, and mortality. The relationship bet...read more
Citations
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Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease
Christopher S. Marnell,Christopher S. Marnell,Alexander G. Bick,Pradeep Natarajan,Pradeep Natarajan +4 more
TL;DR: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with a pro-inflammatory state that has been linked to coronary artery disease, myocardial infarction, and venous thromboembolic disease, as well as prognosis among those with aortic stenosis and heart failure.
Journal ArticleDOI
Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events
Romit Bhattacharya,Romit Bhattacharya,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Mesbah Uddin,Mesbah Uddin,James P. Pirruccello,James P. Pirruccello,Abhishek Niroula,Abhishek Niroula,Christopher J. Gibson,Gabriel K. Griffin,Gabriel K. Griffin,Peter Libby,Benjamin L. Ebert,Alexander G. Bick,Pradeep Natarajan,Pradeep Natarajan +18 more
TL;DR: In this article, the authors examined whether there is an association between diet quality and the prevalence of clonal hematopoiesis of indeterminate potential (CHIP), the expansion of somatic leukemogenic variations in hepatopoietic stem cells, has been associated with atherosclerotic cardiovascular disease.
Journal ArticleDOI
Common and rare variant associations with clonal haematopoiesis phenotypes
Michael D. Kessler,Amy Damask,Sean O’Keeffe,Nilanjana Banerjee,Dadong Li,Kyoko Watanabe,Anthony Marketta,Michael Van Meter,Stefan Semrau,Julie Horowitz,Jing Tang,Jack A. Kosmicki,Veera M. Rajagopal,Yuxin Zou,Yariv Houvras,Arkopravo Ghosh,Christopher Gillies,Joelle Mbatchou,Ryan R. White,Niek Verweij,Jonas Bovijn,Neelroop N. Parikshak,Michelle G. LeBlanc,Marcus B. Jones,David J. Glass,Luca A. Lotta,Michael Cantor,Gurinder S. Atwal,Adam E. Locke,Manuel A. R. Ferreira,Raquel P. Deering,Charles Paulding,Alan R. Shuldiner,Gavin Thurston,Adolfo A. Ferrando,William J Salerno,Jeffrey G. Reid,John D. Overton,Jonathan Marchini,Hyun Min Kang,Aris Baras,Gonçalo R. Abecasis,Eric Jorgenson +42 more
TL;DR: In this paper , exome sequence data from 628,388 individuals was used to identify 24 risk loci in 40,208 carriers of clonal haematopoiesis of indeterminate potential and link them to other conditions including COVID-19, cardiovascular disease and cancer.
Journal ArticleDOI
Clonal hematopoiesis: Mutation-specific adaptation to environmental change.
Marcus A Florez,Brandon T. Tran,Trisha K. Wathan,James DeGregori,Eric M. Pietras,Katherine Y. King +5 more
TL;DR: In this article , the authors discuss how environmental contexts associated with CHIP, such as old age, infections, chemotherapy, or cigarette smoking, alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones.
Journal ArticleDOI
Obesity and Cardiovascular Disease: The Emerging Role of Inflammation.
TL;DR: In this paper, the etiology and pathogenesis of inflammation in obesity associated metabolic disease as well as CVD are reviewed and the available data suggests that anti-inflammatory treatments can be used to reduce CVD, but off-target effects such as increased infection have precluded its broad therapeutic application to date.
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Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
Siddhartha Jaiswal,Pierre Fontanillas,Jason Flannick,Jason Flannick,Alisa K. Manning,Peter V. Grauman,Brenton G. Mar,Brenton G. Mar,R. Coleman Lindsley,Craig H. Mermel,Noël P. Burtt,Alejandro Chavez,John M. Higgins,Vladislav Moltchanov,Vladislav Moltchanov,Frank C. Kuo,Michael J. Kluk,Brian E. Henderson,Leena Kinnunen,Heikki A. Koistinen,Heikki A. Koistinen,Claes Ladenvall,Gad Getz,Adolfo Correa,Benjamin F. Banahan,Stacey Gabriel,Stacey Gabriel,Sekar Kathiresan,Heather M. Stringham,Mark I. McCarthy,Michael Boehnke,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Christopher A. Haiman,Leif Groop,Gil Atzmon,James G. Wilson,Donna Neuberg,David Altshuler,Benjamin L. Ebert +40 more
TL;DR: Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease.
Journal ArticleDOI
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Giulio Genovese,Anna K. Kähler,Robert E. Handsaker,Johan Lindberg,Samuel A. Rose,Samuel F. Bakhoum,Kimberly Chambert,Eran Mick,Benjamin M. Neale,Menachem Fromer,Shaun Purcell,Oscar Svantesson,Mikael Landén,Martin Höglund,Sören Lehmann,Stacey Gabriel,Jennifer L. Moran,Eric S. Lander,Patrick F. Sullivan,Pamela Sklar,Henrik Grönberg,Christina M. Hultman,Steven A. McCarroll +22 more
TL;DR: Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death.
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