Hematopoiesis during Ontogenesis, Adult Life, and Aging
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In the bone marrow of vertebrates, two types of stem cells coexist, i.e., hemopoietic stem cells and mesenchymal stem cells (MSCs).Abstract:
In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two stem cell types and their descendants interact. The descendants of HSCs supply the body with all the mature blood cells, while MSCs give rise to stromal cells that form a niche for HSCs and regulate the process of hematopoiesis. The studies of hematopoiesis were initially based on morphological observations, later extended by the use of physiological methods, and were subsequently augmented by massive application of sophisticated molecular techniques. The combination of these methods produced a wealth of new data on the organization and functional features of hematopoiesis in the ontogenesis of mammals and humans. This review summarizes the current views on hematopoiesis in mice and humans, discusses the development of blood elements and hematopoiesis in the embryo, and describes how the hematopoietic system works in the adult organism and how it changes during aging.read more
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References
More filters
Journal ArticleDOI
Clinical insights into the origins of thrombosis in myeloproliferative neoplasms.
TL;DR: The focus of this review is to critically re-evaluate the clinical burden of thrombosis in the MPNs, to review the clinical associations between clonal hematopoiesis, JAK2V617F burden, inflammation and thromBosis, and to provide insights into novel primary and secondary thROMbosis prevention strategies.
Journal ArticleDOI
DNA Damage Response in Hematopoietic Stem Cell Ageing.
TL;DR: The current understanding of how the DDR determines the HSC fates and finally contributes to organismal ageing is summarized.
Journal ArticleDOI
VEGF-C protects the integrity of the bone marrow perivascular niche in mice.
Shentong Fang,Shentong Fang,Shuo Chen,Harri Nurmi,Harri Nurmi,Veli-Matti Leppänen,Veli-Matti Leppänen,Michael Jeltsch,Michael Jeltsch,David T. Scadden,Lev Silberstein,Hanna K. A. Mikkola,Kari Alitalo,Kari Alitalo +13 more
TL;DR: The results suggest that preservation of the integrity of the perivascular niche via VEGF-C signalling may be exploited therapeutically to enhance hematopoietic regeneration.
Journal ArticleDOI
Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis.
TL;DR: In this paper, the authors provide their perspectives based on the past 8 years of their own laboratory's investigations into these mechanisms and chart a path for integrative studies that, in their opinion, will provide an ideal opportunity to discover HSC and hematopoietic health span-extending interventions.
Journal ArticleDOI
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice.
Maria Carolina Florian,Hanna Leins,Michael Gobs,Yang Han,Gina Marka,Karin Soller,Angelika Vollmer,Vadim Sakk,Kalpana Nattamai,Ahmad Rayes,Xueheng Zhao,Kenneth D.R. Setchell,Medhanie A. Mulaw,Wolfgang Wagner,Yi Zheng,Hartmut Geiger +15 more
TL;DR: It is demonstrated that systemic treatment of aged (75‐week‐old) female C57BL/6 mice with a Cdc42 activity‐specific inhibitor (CASIN) for 4 consecutive days significantly extends average and maximum lifespan.