Journal ArticleDOI
Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma.
Brian A Walker,Paola E. Leone,Paola E. Leone,Paola E. Leone,Matthew W Jenner,Matthew W Jenner,Matthew W Jenner,Cheng Li,Cheng Li,Cheng Li,David Gonzalez,David Gonzalez,David Gonzalez,David W. Johnson,David W. Johnson,David W. Johnson,Fiona M. Ross,Fiona M. Ross,Fiona M. Ross,Faith E. Davies,Faith E. Davies,Faith E. Davies,Gareth J. Morgan,Gareth J. Morgan,Gareth J. Morgan +24 more
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TLDR
For the first time in myeloma, integration of mapping and expression data has allowed us to reduce the complexity of standard gene expression data and identify candidate genes important in both the transition from normal to monoclonal gammopathy of unknown significance (MGUS) to myelomas and in different subgroups within Myeloma.About:
This article is published in Blood.The article was published on 2006-09-01. It has received 188 citations till now. The article focuses on the topics: Monoclonal gammopathy of undetermined significance & Single-nucleotide polymorphism.read more
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Journal ArticleDOI
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
Teru Hideshima,Constantine S. Mitsiades,Giovanni Tonon,Paul G. Richardson,Kenneth C. Anderson +4 more
TL;DR: Recent oncogenomic studies have further advanced the understanding of the molecular pathogenesis of multiple myeloma, providing the framework for new prognostic classification and identifying new therapeutic targets.
Journal ArticleDOI
Mapping complex disease traits with global gene expression
TL;DR: The availability of systematically generated eQTL information could provide immediate insight into a biological basis for disease associations identified through genome-wide association studies, and can help to identify networks of genes involved in disease pathogenesis.
Journal ArticleDOI
International Myeloma Working Group molecular classification of multiple myeloma: spotlight review.
Rafael Fonseca,P L Bergsagel,Johannes Drach,John D. Shaughnessy,Norma C. Gutiérrez,Alexander Keith Stewart,Gareth J. Morgan,B Van Ness,Marta Chesi,Stephane Minvielle,Antonino Neri,Bart Barlogie,W. M. Kuehl,Peter Liebisch,Faith E. Davies,Selina Chen-Kiang,Brian G.M. Durie,Ruben D. Carrasco,Orhan Sezer,Tony Reiman,Linda M. Pilarski,Hervé Avet-Loiseau,Hervé Avet-Loiseau +22 more
TL;DR: In this paper, the authors proposed a framework for the classification of myeloma subtypes and provided recommendations for genetic testing, which needs to be incorporated into daily clinical practice and also as an essential component of all ongoing and future clinical trials.
Journal ArticleDOI
The genetic architecture of multiple myeloma
TL;DR: Using this model system, scientists can study at which points the genetic alterations identified through whole-tumour molecular analyses function in the initiation and progression of myeloma.
SPOTLIGHT REVIEW International Myeloma Working Group molecular classification of multiple myeloma: spotlight review
R Fonseca,P L Bergsagel,Johannes Drach,John D. Shaughnessy,Norma C. Gutiérrez,Alexander Keith Stewart,G Morgan,B Van Ness,Marta Chesi,Stephane Minvielle,Antonino Neri,Bart Barlogie,W. M. Kuehl,Peter Liebisch,Faith E. Davies,Selina Chen-Kiang,Ruben D. Carrasco,Orhan Sezer,Tony Reiman,Linda M. Pilarski,Hervé Avet-Loiseau,Samuel Oschin +21 more
TL;DR: It is proposed that genetic testing needs to be incorporated into daily clinical practice and also as an essential component of all ongoing and future clinical trials.
References
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Journal ArticleDOI
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
TL;DR: It is reported here that inhibition of one of these enzymes, the familial cylindromatosis tumour suppressor gene (CYLD), having no known function, enhances activation of the transcription factor NF-κB, and this effect can be relieved by aspirin derivatives that inhibit NF-σB activity.
Journal ArticleDOI
A Robust Algorithm for Copy Number Detection Using High-Density Oligonucleotide Single Nucleotide Polymorphism Genotyping Arrays
Yasuhito Nannya,Masashi Sanada,Kumi Nakazaki,Noriko Hosoya,Lili Wang,Akira Hangaishi,Mineo Kurokawa,Shigeru Chiba,Dione K. Bailey,Giulia C. Kennedy,Seishi Ogawa +10 more
TL;DR: Improvements in signal-to-noise ratios and the use of an optimized reference make CNAG a useful tool for high-resolution detection of copy number alterations which can help in the understanding of the pathogenesis of cancers and other diseases as well as in exploring the complexities of the human genome.
Journal ArticleDOI
Superiority of tandem autologous transplantation over standard therapy for previously untreated multiple myeloma.
Bart Barlogie,Sundar Jagannath,David H. Vesole,S. Naucke,Bruce D. Cheson,S Mattox,D Bracy,Sydney E. Salmon,Joth Jacobson,John Crowley,Guido Tricot +10 more
TL;DR: Compared to ST, dose intensification with double AT markedly augments tumor cytoreduction, effecting not only higher CR rates but also significantly extending EFS and OS in previously untreated patients with MM.
Journal ArticleDOI
Chromosome translocations in multiple myeloma.
TL;DR: Oncogenes dysregulated by primary IgH translocations in MM do not appear to confer an anti-apoptotic effect, but instead increase proliferation and/or inhibit differentiation.
Journal Article
WWOX, a Novel WW Domain-containing Protein Mapping to Human Chromosome 16q23.3-24.1, a Region Frequently Affected in Breast Cancer
Andrzej K. Bednarek,Kendra J. Laflin,Rachael L. Daniel,Qiaoyin Liao,Kathleen A. Hawkins,C. Marcelo Aldaz +5 more
TL;DR: Interestingly, the presence of WW domains in the structure of WWOX indicate the likelihood that this protein physically interacts with other proteins, and it is speculated that WWOX may span the yet uncharacterized common fragile site FRA16D region.
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