Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17
TLDR
Evidence is presented that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion, which suggests that during a secondary immune response, IL- 23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-01-17 and is currently open access. It has received 1909 citations till now. The article focuses on the topics: Interleukin 25 & Interleukin 21.read more
Citations
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Journal ArticleDOI
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
Journal ArticleDOI
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivaylo I. Ivanov,Brent S. McKenzie,Liang Zhou,Carlos E. Tadokoro,Alice Lepelley,Juan J. Lafaille,Daniel J. Cua,Dan R. Littman +7 more
TL;DR: It is shown that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage of proinflammatory T helper cells and its potential as a therapeutic target in inflammatory diseases is highlighted.
Journal ArticleDOI
Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
Journal ArticleDOI
IL-17 and Th17 Cells.
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
Journal ArticleDOI
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
TL;DR: In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
References
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Journal ArticleDOI
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Birgit Oppmann,Robin Lesley,Bianca Blom,Jackie C. Timans,Yuming Xu,Brisdell Hunte,Felix Vega,Nancy Yu,Jing Wang,Komal Singh,Francesca Zonin,Elena Vaisberg,Tatyana Churakova,Man ru Liu,Daniel M. Gorman,Janet Wagner,Sandra Zurawski,Yong-Jun Liu,John S. Abrams,Kevin W. Moore,Donna Rennick,Rene de Waal-Malefyt,Charles H. Hannum,J. Fernando Bazan,Robert A. Kastelein +24 more
TL;DR: Human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells and induces strong proliferation of mouse memory T cells.
Journal ArticleDOI
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
Shigeru Kotake,Nobuyuki Udagawa,Naoyuki Takahashi,Kenichiro Matsuzaki,Kanami Itoh,Shigeru Ishiyama,Seiji Saito,Kazuhiko Inoue,Naoyuki Kamatani,Matthew T. Gillespie,T. John Martin,Tatsuo Suda +11 more
TL;DR: It is suggested that IL-17 first acts on osteoblasts, which stimulates both COX-2-dependent PGE2 synthesis and ODF gene expression, which in turn induce differentiation of osteoclast progenitors into mature osteoclasts, and that IL -17 is a crucial cytokine for osteoclastic bone resorption in RA patients.
Journal ArticleDOI
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.
François Fossiez,Odile Djossou,Pascale Chomarat,Leopoldo Flores-Romo,Smina Ait-Yahia,C Maat,Jean-Jacques Pin,Pierre Garrone,Eric Garcia,Sem Saeland,D Blanchard,Claude Gaillard,B Das Mahapatra,E Rouvier,Pierre Golstein,Jacques Banchereau,Serge Lebecque +16 more
TL;DR: Observations suggest that hIL-17 may constitute an early initiator of the T cell-dependent inflammmatory reaction; and an element of the cytokine network that bridges the immune system to hematopoiesis.
Journal Article
Il-17 stimulates the production and expression of proinflammatory cytokines, il-beta and tnf-alpha , by human macrophages
Dragan V. Jovanovic,J. A. Di Battista,Johanne Martel-Pelletier,F C Jolicoeur,Yulan He,Mengkun Zhang,François Mineau,J.-P. Pelletier +7 more
TL;DR: A pivotal role for IL-17 is suggested in initiating and/or sustaining an inflammatory response to proinflammatory mediators by human macrophages in response to recombinant human (rh) IL- 17.
Journal ArticleDOI
Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium.
Martine Chabaud,Jean Marc Durand,Nicolas Buchs,François Fossiez,Guillaume Page,Lucien Frappart,Pierre Miossec +6 more
TL;DR: It is indicated that IL-17 contributes to the active, proinflammatory pattern that is characteristic of RA through the contribution of some Th1-like T cells appear to mediate synovial inflammation.
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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
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