Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target
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TLDR
Iron depletion, most frequently achieved by phlebotomy, has been shown to decrease metabolic alterations and liver enzymes in controlled studies in NAFLD, and represents also a treatable condition.About:
This article is published in Journal of Hepatology.The article was published on 2011-10-01 and is currently open access. It has received 276 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease & Fatty liver.read more
Citations
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Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease
Mario Masarone,Valerio Rosato,Marcello Dallio,Antonietta Gerarda Gravina,Andrea Aglitti,Carmelina Loguercio,Alessandro Federico,Marcello Persico +7 more
TL;DR: The aim of this review is to give a comprehensive insight on the present researches and findings on the role of oxidative stress mechanisms in the pathogenesis and pathophysiology of NAFLD.
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Iron and diabetes risk.
TL;DR: Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failure and insulin resistance and regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role.
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Obesity as an Emerging Risk Factor for Iron Deficiency
TL;DR: This review summarizes the current understanding of the dysregulation of iron homeostasis in obesity and identifies Obesity-associated inflammation is tightly linked to iron deficiency and involves impaired duodenal iron absorption associated with low expression of duodanal ferroportin (FPN) along with elevated hepcidin concentrations.
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Involvement of free radicals and oxidative stress in NAFLD/NASH
TL;DR: The detailed analysis of lipid oxidation products shows the involvement of free radicals in the pathogenesis of NAFLD and NASH, taking characteristic features of free radical-mediated oxidation into consideration.
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Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases.
TL;DR: A synopsis of AA metabolism in human health, tissue homeostasis, and immunity is presented, and the role of the AA metabolome in diverse pathophysiological conditions and diseases is explored.
References
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Journal ArticleDOI
Leptin and the regulation of body weight in mammals
TL;DR: The role of leptin in the control of body weight and its relevance to the pathogenesis of obesity are reviewed.
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Increased oxidative stress in obesity and its impact on metabolic syndrome
Shigetada Furukawa,Takuya Fujita,Michio Shimabukuro,Masanori Iwaki,Yukio Yamada,Yoshimitsu Nakajima,Osamu Nakayama,Makoto Makishima,Morihiro Matsuda,Iichiro Shimomura +9 more
TL;DR: It is suggested that increased oxidative stress in accumulated fat is an early instigator of metabolic syndrome and that the redox state in adipose tissue is a potentially useful therapeutic target for obesity-associated metabolic syndrome.
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Nonalcoholic fatty liver disease.
TL;DR: Nonalcoholic fatty liver disease is associated with an increased risk of all-cause death, probably because of complications of insulin resistance such as vascular disease, as well as due to cirrhosis and hepatocellular carcinoma, which occurs in a minority of patients.
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The hormone resistin links obesity to diabetes
Claire M. Steppan,Shannon T. Bailey,Savitha Bhat,Elizabeth J. Brown,Ronadip R. Banerjee,Christopher M. Wright,Hiralben R. Patel,Rexford S. Ahima,Mitchell A. Lazar +8 more
TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.