Lysine Succinylation and Lysine Malonylation in Histones
Zhongyu Xie,Junbiao Dai,Junbiao Dai,Lunzhi Dai,Minjia Tan,Zhongyi Cheng,Yeming Wu,Jef D. Boeke,Yingming Zhao +8 more
TLDR
The identification and validation of a new type of PTM in histones, lysine succinylation, and it is demonstrated that this histone PTM is present in all eukaryotic cells the authors examined.About:
This article is published in Molecular & Cellular Proteomics.The article was published on 2012-05-01 and is currently open access. It has received 464 citations till now. The article focuses on the topics: Protein succinylation & Succinylation.read more
Citations
More filters
Journal ArticleDOI
The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
Journal ArticleDOI
The Metabolic Signature of Macrophage Responses.
TL;DR: Recent findings linking macrophage functions and metabolism are discussed, which show that pro- and anti-inflammatory macrophages are characterized by specific pathways that regulate the metabolism of lipids and amino acids and affect their responses.
Journal ArticleDOI
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Jeongsoon Park,Yue Chen,Daniel X. Tishkoff,Chao Peng,Minjia Tan,Minjia Tan,Lunzhai Dai,Zhongyu Xie,Yi Zhang,Bernadette M. M. Zwaans,Mary E. Skinner,David B. Lombard,Yingming Zhao,Yingming Zhao +13 more
TL;DR: Systematic profiling of the mammalian succinylome reveals widespread roles for lysine succinylation in regulating metabolism and potentially other cellular functions, and identifies two protein complexes identified in the analysis.
Journal ArticleDOI
Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5
Minjia Tan,Chao Peng,Kristin A. Anderson,Peter Chhoy,Zhongyu Xie,Lunzhi Dai,Jeongsoon Park,Yue Chen,He Huang,Yi Zhang,Jennifer Ro,Gregory R. Wagner,Michelle F. Green,Andreas Stahl Madsen,Jessica Schmiesing,Brett S. Peterson,Guofeng Xu,Olga Ilkayeva,Michael J. Muehlbauer,Thomas Braulke,Chris Mühlhausen,Donald S. Backos,Christian A. Olsen,Peter J. McGuire,Scott D. Pletcher,David B. Lombard,Matthew D. Hirschey,Yingming Zhao,Yingming Zhao +28 more
TL;DR: The identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine glutarylation (Kglu) is reported and it is demonstrated that the previously annotated deacetylase, sirtuin 5 (SIRT5), is aLysine deglutarylase.
Journal ArticleDOI
Metabolic regulation of gene expression through histone acylations
TL;DR: A model is proposed to explain the present understanding of how differential histone acylation is regulated by the metabolism of the different acyl-CoA forms, which in turn modulates the regulation of gene expression.
References
More filters
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.
Nathaniel D. Heintzman,Rhona K. Stuart,Gary C. Hon,Yutao Fu,Christina W. Ching,R. David Hawkins,Leah O. Barrera,Sara Van Calcar,Chunxu Qu,Keith A. Ching,Wei Wang,Zhiping Weng,Roland Green,Gregory E. Crawford,Bing Ren +14 more
TL;DR: Insight is given into the connections between chromatin modifications and transcriptional regulatory activity and a novel functional enhancer for the carnitine transporter SLC22A5 (OCTN2) is uncovered, providing a new tool for the functional annotation of the human genome.
Journal ArticleDOI
The diverse functions of histone lysine methylation.
Cyrus Martin,Yi Zhang +1 more
TL;DR: Recent advances in understanding of how lysine methylation functions in these diverse biological processes are summarized, and questions that need to be addressed in the future are raised.
Journal ArticleDOI
Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey
Sung Chan Kim,Robert Sprung,Yue Chen,Yingda Xu,Haydn L. Ball,Jimin Pei,Tzuling Cheng,Yoonjung Kho,Hao Xiao,Lin Xiao,Nick V. Grishin,Michael A. White,Xiang-Jiao Yang,Yingming Zhao +13 more
TL;DR: This study reveals previously unappreciated roles for lysine acetylation in the regulation of diverse cellular pathways outside of the nucleus, including many longevity regulators and metabolism enzymes.