SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Jeongsoon Park,Yue Chen,Daniel X. Tishkoff,Chao Peng,Minjia Tan,Minjia Tan,Lunzhai Dai,Zhongyu Xie,Yi Zhang,Bernadette M. M. Zwaans,Mary E. Skinner,David B. Lombard,Yingming Zhao,Yingming Zhao +13 more
TLDR
Systematic profiling of the mammalian succinylome reveals widespread roles for lysine succinylation in regulating metabolism and potentially other cellular functions, and identifies two protein complexes identified in the analysis.About:
This article is published in Molecular Cell.The article was published on 2013-06-27 and is currently open access. It has received 720 citations till now. The article focuses on the topics: Protein succinylation & Succinylation.read more
Citations
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Journal ArticleDOI
The growing landscape of lysine acetylation links metabolism and cell signalling
TL;DR: These emerging findings point to new functions for different lysine acylations and deacylating enzymes and also highlight the mechanisms by which acetylation regulates various cellular processes.
Journal ArticleDOI
The Metabolic Signature of Macrophage Responses.
TL;DR: Recent findings linking macrophage functions and metabolism are discussed, which show that pro- and anti-inflammatory macrophages are characterized by specific pathways that regulate the metabolism of lipids and amino acids and affect their responses.
Journal ArticleDOI
Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5
Minjia Tan,Chao Peng,Kristin A. Anderson,Peter Chhoy,Zhongyu Xie,Lunzhi Dai,Jeongsoon Park,Yue Chen,He Huang,Yi Zhang,Jennifer Ro,Gregory R. Wagner,Michelle F. Green,Andreas Stahl Madsen,Jessica Schmiesing,Brett S. Peterson,Guofeng Xu,Olga Ilkayeva,Michael J. Muehlbauer,Thomas Braulke,Chris Mühlhausen,Donald S. Backos,Christian A. Olsen,Peter J. McGuire,Scott D. Pletcher,David B. Lombard,Matthew D. Hirschey,Yingming Zhao,Yingming Zhao +28 more
TL;DR: The identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine glutarylation (Kglu) is reported and it is demonstrated that the previously annotated deacetylase, sirtuin 5 (SIRT5), is aLysine deglutarylase.
Journal ArticleDOI
Metabolic regulation of gene expression through histone acylations
TL;DR: A model is proposed to explain the present understanding of how differential histone acylation is regulated by the metabolism of the different acyl-CoA forms, which in turn modulates the regulation of gene expression.
Journal ArticleDOI
SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
Matthew J. Rardin,Wenjuan He,Yuya Nishida,John C. Newman,Chris Carrico,Steven R. Danielson,Ailan Guo,Philipp Gut,Alexandria K. Sahu,Biao Li,Radha Uppala,Mark Fitch,Timothy Riiff,Lei Zhu,Jing Zhou,Daniel Mulhern,Robert Stevens,Olga Ilkayeva,Christopher B. Newgard,Matthew P. Jacobson,Marc K. Hellerstein,Eric S. Goetzman,Bradford W. Gibson,Bradford W. Gibson,Eric Verdin +24 more
TL;DR: Findings establish SIRT5 as a global regulator of lysine succinylation in mitochondria and present a mechanism for inhibition of ketogenesis through HMGCS2.
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