Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase.
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TLDR
The results strongly suggested that the fatty acid inhibition of glucose-induced l-PK transcription resulted from AMPK phosphorylation of ChREBP at Ser568, which inactivated the DNA binding activity.About:
This article is published in Journal of Biological Chemistry.The article was published on 2002-02-08 and is currently open access. It has received 391 citations till now. The article focuses on the topics: AMPK & AMP-activated protein kinase.read more
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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
TL;DR: A number of recent breakthroughs in the mechanistic understanding of AMPK function are reviewed, focusing on a number of newly identified downstream effectors of AM PK.
Journal ArticleDOI
Molecular mediators of hepatic steatosis and liver injury
TL;DR: Recent advances in the understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis are highlighted.
Journal ArticleDOI
AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig,Reuben J. Shaw +1 more
TL;DR: How AMPK functions as a central mediator of the cellular response to energetic stress and mitochondrial insults and coordinates multiple features of autophagy and mitochondrial biology is discussed.
Journal ArticleDOI
Cellular and molecular mechanisms of metformin: an overview
Benoit Viollet,Benoit Viollet,Benoit Viollet,Bruno Guigas,Nieves Sanz Garcia,Nieves Sanz Garcia,Nieves Sanz Garcia,Jocelyne Leclerc,Jocelyne Leclerc,Jocelyne Leclerc,Marc Foretz,Marc Foretz,Marc Foretz,Fabrizio Andreelli +13 more
TL;DR: Emerging new therapeutic areas for metformin will be reviewed together with recent findings from pharmacogenetic studies linking genetic variations to drug response, a promising new step towards personalized medicine in the treatment of T2D.
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Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers.
TL;DR: It is concluded that butyrate enhances the intestinal barrier by regulating the assembly of tight junctions and this dynamic process is mediated by the activation of AMPK.
References
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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
TL;DR: AMP-activated protein kinase and SNF1-related protein kinases in higher plants are likely to be involved in the response of plant cells to environmental and/or nutritional stress.
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The AMP‐Activated Protein Kinase
D. Grahame Hardie,David Carling +1 more
TL;DR: The central hypothesis is that the AMP-activated protein kinase cascade appears to be an ancient system which evolved to protect cells against the effects of nutritional or environmental stress, and protects the cell by switching off ATP-consuming pathways and switching on alternative pathways for ATP generation.
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Cytosolic phosphorylation potential.
TL;DR: Agreement between two highly active enzyme systems in the same compartment is taken as evidence of the existence of near-equilibrium in both these systems and suggests that free cytosolic [sigma ADP] is probably 20-fold lower than measured cell ADP content in mitochondrial-containing tissues.
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A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
Hiromi Yamashita,Makoto Takenoshita,Masaharu Sakurai,Richard K. Bruick,William J. Henzel,Wendy Shillinglaw,David Arnot,Kosaku Uyeda +7 more
TL;DR: The purification and identification of a transcription factor that recognizes the carbohydrate response element (ChRE) within the promoter of the L-type pyruvate kinase (LPK) gene is reported, suggesting a possible mode of glucose-responsive regulation.
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Fatty acid regulation of gene transcription.
TL;DR: The mechanism(s) by which FAs modulate gene transcription still remains largely unresolved and the purpose of the present review is to address this important issue.