Journal ArticleDOI
Megalin and cubilin: multifunctional endocytic receptors
TLDR
The ability to take up substances from the surrounding environment not only provides cells with vital nutrients, but also enables the selective transport of substances from one compartment to another.Abstract:
The ability to take up substances from the surrounding environment not only provides cells with vital nutrients, but also enables the selective transport of substances from one compartment to another. Megalin and cubilin are two structurally different endocytic receptors that interact to serve such functions. Evidence has accumulated in recent years to indicate that these receptors have important functions in both normal physiology and pathology.read more
Citations
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Unraveling the mysteries of serum albumin—more than just a serum protein
TL;DR: The intracellular localization of albumin was assessed in order to understand the mechanisms and pathways responsible for its uptake, distribution and catabolism in multiple tissues, and this is reviewed herein.
Journal ArticleDOI
Placental Origins of Chronic Disease.
TL;DR: The complex relationships between the placental phenotype and developmental programming of chronic disease in the offspring are explored, offering a new approach to the prevention of disorders such as cardiovascular disease, diabetes, and obesity, which are reaching epidemic proportions.
Journal ArticleDOI
V‐ATPase Interacts with ARNO and Arf6 in Early Endosomes and Regulates the Protein Degradative Pathway
Andrés Hurtado-Lorenzo,Mhairi A. Skinner,Jaafar El Annan,Masamitsu Futai,Ge-Hong Sun-Wada,Sylvain G. Bourgoin,James E. Casanova,Alan G. Wildeman,Dennis A. Ausiello,Dennis Brown,Vladimir Marshansky +10 more
TL;DR: In this paper, the authors demonstrate that the recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification.
Journal ArticleDOI
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway
Andrés Hurtado-Lorenzo,Mhairi A. Skinner,Jaafar El Annan,Masamitsu Futai,Ge-Hong Sun-Wada,Sylvain G. Bourgoin,James E. Casanova,Alan G. Wildeman,Shaliha Bechoua,Dennis A. Ausiello,Dennis Brown,Vladimir Marshansky +11 more
TL;DR: Data demonstrate the crucial role of early endosomal acidification and V-ATPase/ARNO/Arf6 interactions in the regulation of the endocytic degradative pathway and indicate that V-atPase could modulate membrane trafficking by recruiting and interacting with ARNO and Arf6; characteristics that are consistent with the role of V- ATPase as an essential component of theendosomal pH-sensing machinery.
Journal ArticleDOI
Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances.
TL;DR: The mechanisms governing the major modes of receptor-mediated endocytosis used in drug delivery are outlined and recent approaches using these as targets for in vivo drug delivery of nanoparticles are highlighted.
References
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Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Marion Trommsdorff,Michael Gotthardt,Thomas Hiesberger,John M. Shelton,Walter Stockinger,Johannes Nimpf,Robert E. Hammer,James A. Richardson,Joachim Herz +8 more
TL;DR: It is suggested that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1, a cytosolic protein that activates tyrosine kinases.
Journal ArticleDOI
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Sherry L. Abboud,David J. Haile +1 more
TL;DR: Data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism.
Journal ArticleDOI
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.
TL;DR: A review of published data revealed NPXY sequences in cytoplasmic domains of at least 10 other cell surface proteins, including tyrosine kinase-linked receptors of the epidermal growth factor and insulin receptor family, the beta-subunits of three integrin receptors, and the amyloid A4 precursor protein.
Journal ArticleDOI
An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3
Anders Nykjaer,Duska Dragun,Diego J. Walther,Henrik Vorum,Christian Jacobsen,Joachim Herz,Flemming Melsen,E. I. Christensen,Thomas E. Willnow +8 more
TL;DR: It is demonstrated here that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes, andMegalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease.