Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation
Daniela Weber,Robert R. Jenq,Jonathan U. Peled,Jonathan U. Peled,Ying Taur,Ying Taur,Andreas Hiergeist,Josef Koestler,Katja Dettmer,Markus Weber,Daniel Wolff,Joachim Hahn,Eric G. Pamer,Eric G. Pamer,Wolfgang Herr,André Gessner,Peter J. Oefner,Marcel R.M. van den Brink,Ernst Holler +18 more
TLDR
The poor outcome associated with early administration of antibiotic therapy that is active against commensal organisms, and specifically the possibly protective Clostridiales, calls for the use of Clostbridiales-sparing antibiotics and rapid restoration of microbiota diversity after cessation of antibiotic treatment.About:
This article is published in Biology of Blood and Marrow Transplantation.The article was published on 2017-05-01 and is currently open access. It has received 170 citations till now. The article focuses on the topics: Transplantation.read more
Citations
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Journal ArticleDOI
Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation
Jonathan U. Peled,Antonio L.C. Gomes,Sean M Devlin,Eric R. Littmann,Ying Taur,Anthony D. Sung,Daniela Weber,Daigo Hashimoto,Ann E. Slingerland,John B. Slingerland,Molly Maloy,Annelie Clurman,Christoph K. Stein-Thoeringer,Kate A. Markey,Melissa D. Docampo,Marina Burgos da Silva,Niloufer Khan,André Gessner,Julia A. Messina,Kristi Romero,Meagan V. Lew,Amy Bush,Lauren Bohannon,Daniel G. Brereton,Emily Fontana,Luigi A Amoretti,Roberta J. Wright,Gabriel K Armijo,Yusuke Shono,Miriam Sanchez-Escamilla,Nerea Castillo Flores,Ana Alarcon Tomas,Richard J. Lin,Lucrecia Yáñez San Segundo,Gunjan L. Shah,Christina Cho,Michael Scordo,Ioannis Politikos,Kasumi Hayasaka,Yuta Hasegawa,Boglarka Gyurkocza,Doris M. Ponce,Juliet N. Barker,Miguel-Angel Perales,Sergio Giralt,Robert R. Jenq,Takanori Teshima,Nelson J. Chao,Ernst Holler,Joao B. Xavier,Eric G. Pamer,Marcel R.M. van den Brink +51 more
TL;DR: In this article, the relationship between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation has been described in single-center studies in the US.
Journal ArticleDOI
Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant
Ying Taur,Katharine Z. Coyte,Katharine Z. Coyte,Katharine Z. Coyte,Jonas Schluter,Elizabeth Robilotti,Cesar J. Figueroa,Mergim Gjonbalaj,Eric R. Littmann,Lilan Ling,Liza Miller,Liza Miller,Yangtsho Gyaltshen,Yangtsho Gyaltshen,Emily Fontana,Sejal Morjaria,Boglarka Gyurkocza,Miguel-Angel Perales,Hugo Castro-Malaspina,Roni Tamari,Doris M. Ponce,Guenther Koehne,Juliet N. Barker,Ann A. Jakubowski,Esperanza B. Papadopoulos,Parastoo B. Dahi,Craig S. Sauter,Brian C. Shaffer,James W. Young,James W. Young,James W. Young,Jonathan U. Peled,Richard Meagher,Robert R. Jenq,Marcel R.M. van den Brink,Marcel R.M. van den Brink,Sergio Giralt,Eric G. Pamer,Joao B. Xavier +38 more
TL;DR: It is shown that auto-FMT reconstitutes major commensal bacterial populations, thereby reestablishing the patient’s gut microbiota diversity and composition and demonstrating the potential for fecal sample banking and posttreatment remediation of a patient's gut microbiota after microbiota-depleting antibiotic treatment during allo-HSCT.
Journal ArticleDOI
Lactose drives Enterococcus expansion to promote graft-versus-host disease.
C. K. Stein-Thoeringer,C. K. Stein-Thoeringer,C. K. Stein-Thoeringer,K. B. Nichols,K. B. Nichols,A. Lazrak,A. Lazrak,Melissa D. Docampo,Melissa D. Docampo,Ann E. Slingerland,Ann E. Slingerland,J. B. Slingerland,J. B. Slingerland,Annelie Clurman,G. Armijo,G. Armijo,Antonio L.C. Gomes,Antonio L.C. Gomes,Yusuke Shono,Yusuke Shono,Anna Staffas,Anna Staffas,M. Burgos da Silva,M. Burgos da Silva,Sean M. Devlin,Kate A. Markey,Kate A. Markey,D. Bajic,R. Pinedo,A. Tsakmaklis,Eric R. Littmann,Eric R. Littmann,Alessandro Pastore,Ying Taur,Sebastien Monette,M. E. Arcila,Amanda J. Pickard,Molly Maloy,Roberta J. Wright,Luigi A Amoretti,Emily Fontana,D. Pham,M. A. Jamal,Daniela Weber,Anthony D. Sung,Daigo Hashimoto,C. Scheid,Joao B. Xavier,Julia A. Messina,Kristi Romero,Meagan V. Lew,Amy Bush,Lauren Bohannon,Koji Hayasaka,Yuta Hasegawa,M. J. G. T. Vehreschild,M. J. G. T. Vehreschild,Justin R. Cross,Doris M. Ponce,Doris M. Ponce,Miguel-Angel Perales,Miguel-Angel Perales,Sergio Giralt,Sergio Giralt,Robert R. Jenq,Takanori Teshima,Ernst Holler,Nelson J. Chao,Eric G. Pamer,Eric G. Pamer,Eric G. Pamer,Jonathan U. Peled,Jonathan U. Peled,M.R.M. van den Brink,M.R.M. van den Brink +74 more
TL;DR: Lactose is reported as a common nutrient that drives expansion of a commensal bacterium that exacerbates an intestinal and systemic inflammatory disease and is associated with graft-versus-host disease (GVHD) and mortality in patients.
Journal ArticleDOI
Gut microbiota injury in allogeneic haematopoietic stem cell transplantation.
TL;DR: The potential role of intestinal flora in patients with haematopoietic malignancies who have received an allo-HSCT and in whether the microbiota affects clinical outcomes is discussed, including GVHD, relapse, infections and transplant-related mortality.
Journal ArticleDOI
Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity.
Zachariah DeFilipp,Jonathan U. Peled,Jonathan U. Peled,Shuli Li,Jasmin Mahabamunuge,Zeina Dagher,Ann E. Slingerland,Ann E. Slingerland,Candice Del Rio,Betsy Valles,Maria E. Kempner,Melissa Smith,Jami Brown,Bimalangshu R. Dey,Areej El-Jawahri,Steven L. McAfee,Thomas R. Spitzer,Karen K. Ballen,Anthony D. Sung,Tara Dalton,Julia A. Messina,Katja Dettmer,Gerhard Liebisch,Peter J. Oefner,Ying Taur,Ying Taur,Eric G. Pamer,Eric G. Pamer,Ernst Holler,Michael K. Mansour,Marcel R.M. van den Brink,Marcel R.M. van den Brink,Elizabeth L. Hohmann,Robert R. Jenq,Yi Bin Chen +34 more
TL;DR: Analysis of stool composition and urine 3-indoxyl sulfate concentration indicated improvement in intestinal microbiome diversity after FMT that was associated with expansion of stool-donor taxa.
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