MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation.
Francisco J. Ortega,José María Moreno-Navarrete,Gerard Pardo,Mònica Sabater,Manuela Hummel,Anna Ferrer,José Ignacio Rodríguez-Hermosa,Bartomeu Ruiz,Wifredo Ricart,Belén Peral,José Manuel Fernández-Real +10 more
TLDR
The remarkable inverse miRNA profile revealed for human pre-adipocytes and mature adipocytes hints at a closely crosstalk between miRNAs and adipogenesis.Abstract:
Background
Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, to date no study is available, to our knowledge, regarding miRNAs expression profile during human adipogenesis. Thereby, the aim of this study was to investigate whether miRNA pattern in human fat cells and subcutaneous adipose tissue is associated to obesity and co-morbidities and whether miRNA expression profile in adipocytes is linked to adipogenesis.read more
Citations
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Journal ArticleDOI
Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomas Thomou,Marcelo A. Mori,Jonathan M. Dreyfuss,Jonathan M. Dreyfuss,Masahiro Konishi,Masaji Sakaguchi,Christian Wolfrum,Tata Nageswara Rao,Tata Nageswara Rao,Jonathon N. Winnay,Ruben Garcia-Martin,Steven K. Grinspoon,Phillip Gorden,C. Ronald Kahn +13 more
TL;DR: Transplantation of both white and brown adipose tissue—brown especially—into ADicerKO mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21.
Journal ArticleDOI
MicroRNAs in metabolism and metabolic disorders.
Veerle Rottiers,Anders M. Näär +1 more
TL;DR: Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that mi RNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.
Journal ArticleDOI
MicroRNAs 103 and 107 regulate insulin sensitivity
Mirko Trajkovski,Jean Hausser,Jean Hausser,Jiirgen Soutschek,Bal Bhat,Akinc Akin,Mihaela Zavolan,Markus H. Heim,Markus H. Heim,Markus Stoffel +9 more
TL;DR: It is shown that the expression of microRNAs 103 and 107 (miR-103/107) is upregulated in obese mice and caveolin-1, a critical regulator of the insulin receptor, is identified as a direct target gene of miR- 103/107, as a new target for the treatment of type 2 diabetes and obesity.
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
Journal ArticleDOI
miR-33 links SREBP-2 induction to repression of sterol transporters
TL;DR: This work shows that miR-33 is encoded within SREBP-2 and that both mRNAs are coexpressed, and identifies sequences in the 3′ UTR of ABCA1 and ABCG1, sterol transporter genes both previously shown to be regulated by LXR, as targets for mi R-33–mediated silencing.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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MicroRNAs: Target Recognition and Regulatory Functions
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
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MicroRNAs Modulate Hematopoietic Lineage Differentiation
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