Mitochondria: The Next (Neurode)Generation
Eric A. Schon,Serge Przedborski +1 more
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TLDR
These new mechanisms by which mitochondria may also be linked to neurodegeneration will likely have far-reaching implications for the understanding of the pathophysiology and treatment of adult-onset neuro degenerative disorders.About:
This article is published in Neuron.The article was published on 2011-06-23 and is currently open access. It has received 509 citations till now. The article focuses on the topics: mitochondrial fusion & Neurodegeneration.read more
Citations
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Journal ArticleDOI
Mitochondria: In Sickness and in Health
TL;DR: This work provides a current view of how mitochondrial functions impinge on health and disease and identifies mitochondrial dysfunction as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders.
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Physiological roles of mitochondrial reactive oxygen species.
Laura A. Sena,Navdeep S. Chandel +1 more
TL;DR: More and more evidence suggests that mROS are critical for healthy cell function, and this evidence is discussed following some background on the generation and regulation ofmROS.
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Mitochondrial form and function
TL;DR: Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction.
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PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Xinnan Wang,Dominic Winter,Ghazaleh Ashrafi,Ghazaleh Ashrafi,Julia S. Schlehe,Yao Liang Wong,Dennis J. Selkoe,Sarah E. Rice,Judith A. Steen,Matthew J. LaVoie,Thomas Schwarz,Thomas Schwarz +11 more
TL;DR: It is proposed that PINK1 phosphorylation of substrates triggers the subsequent action of Parkin and the proteasome, and the PINK/Parkin pathway may quarantine damaged mitochondria prior to their clearance.
Journal ArticleDOI
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Charleen T. Chu,Jing Ji,Ruben K. Dagda,Jianfei Jiang,Yulia Y. Tyurina,Alexandr A. Kapralov,Vladimir A. Tyurin,Naveena Yanamala,Indira H. Shrivastava,Dariush Mohammadyani,Kent Z.Q. Wang,Jianhui Zhu,Judith Klein-Seetharaman,Krishnakumar Balasubramanian,Andrew A. Amoscato,Grigory G. Borisenko,Zhentai Huang,Aaron M. Gusdon,Amin Cheikhi,Erin Steer,Ruth Wang,Catherine J. Baty,Simon C. Watkins,Ivet Bahar,Hülya Bayır,Valerian E. Kagan +25 more
TL;DR: Red redistribution of cardiolipin serves as an ‘eat-me’ signal for the elimination of damaged mitochondria from neuronal cells as well as the engulfment of mitochondria by the autophagic system.
References
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Parkinson's disease: Mechanisms and models
TL;DR: PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Pere Puigserver,Zhidan Wu,Cheol Won Park,Reed A. Graves,Margaret E. Wright,Bruce M. Spiegelman +5 more
TL;DR: Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.
Journal ArticleDOI
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig,Alvaro A. Elorza,Anthony J.A. Molina,Anthony J.A. Molina,Hibo Mohamed,Jakob D. Wikstrom,Gil Walzer,Linsey Stiles,Sarah E. Haigh,Steve Katz,Guy Las,Joseph Alroy,Min Wu,Bénédicte F. Py,Junying Yuan,Jude T. Deeney,Barbara E. Corkey,Orian S. Shirihai +17 more
TL;DR: Pulse chase and arrest of autophagy at the pre‐proteolysis stage reveal that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagic.
Journal ArticleDOI
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Derek P. Narendra,Seok Min Jin,Atsushi Tanaka,Der-Fen Suen,Clement A. Gautier,Jie Shen,Mark R. Cookson,Richard J. Youle +7 more
TL;DR: The authors suggest that PINK1 and Parkin form a pathway that senses damaged mitochondria and selectively targets them for degradation.
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler,Kira M. Holmström,Diana Skujat,Fabienne C. Fiesel,Oliver Rothfuss,Philipp J. Kahle,Wolfdieter Springer +6 more
TL;DR: Functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease, are provided.
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