Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more
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A group of international experts came together through a joint initiative by the European Centre for Disease Prevention and Control and the Centers for Disease Control and Prevention, to create a standardized international terminology with which to describe acquired resistance profiles in Staphylococcus aureus, Enterococcus spp.About:
This article is published in Clinical Microbiology and Infection.The article was published on 2012-03-01 and is currently open access. It has received 8695 citations till now. The article focuses on the topics: Extensively drug resistant bacteria & Multiple drug resistance.read more
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EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
Paolo Angeli,Mauro Bernardi,Càndid Villanueva,Claire Francoz,Rajeshwar P. Mookerjee,Jonel Trebicka,Aleksander Krag,Wim Laleman,Pere Ginès +8 more
TL;DR: The panel of experts, having emphasised the importance of initiating aetiologic treatment for any degree of hepatic disease at the earliest possible stage, extended its work to all the complications of cirrhosis which had not been covered by the European Association for the Study of the Liver guidelines.
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Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes
TL;DR: Genotypic and phenotypic methods that provide relevant information for diagnostic laboratories are presented and recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyXin resistance determinant MCR-1 are presented.
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International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia
Antoni Torres,Michael S. Niederman,Jean Chastre,Santiago Ewig,Patricia Fernandez-Vandellos,Håkan Hanberger,Marin H. Kollef,Gianluigi Li Bassi,Carlos M. Luna,Ignacio Martin-Loeches,J. Artur Paiva,Robert C. Read,David Rigau,Jean-François Timsit,Tobias Welte,Richard G. Wunderink +15 more
TL;DR: The panel selected seven PICO (population–intervention–comparison–outcome) questions that generated a series of recommendations for HAP/VAP diagnosis, treatment and prevention that were adopted by the ERS/ESICM/ESCMID/ALAT panel.
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Antimicrobial resistance in ESKAPE pathogens
David M. P. De Oliveira,Brian M. Forde,Timothy J. Kidd,Patrick N A Harris,Mark A. Schembri,Scott A. Beatson,David L. Paterson,Mark J. Walker +7 more
TL;DR: The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antim antibiotic resistance surveillance.
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Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013
Rajiv Jalan,Javier Fernández,Reiner Wiest,Bernd Schnabl,Richard Moreau,Paolo Angeli,Vanessa Stadlbauer,Thierry Gustot,Mauro Bernardi,Rafael Cantón,Agustín Albillos,Frank Lammert,Alexander Wilmer,Rajeshwar P. Mookerjee,Jordi Vila,R. Garcia-Martinez,Julia Wendon,José Such,Juan Córdoba,Arun J. Sanyal,Guadalupe Garcia-Tsao,Vicente Arroyo,Andrew K. Burroughs,Pere Ginès +23 more
TL;DR: An in-depth review and a position statement on bacterial infections in cirrhosis are reported, which suggest that research on biomarkers of early infection may be useful in early diagnosis and treatment of infections.
References
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Management of multidrug-resistant organisms in health care settings, 2006.
TL;DR: This guideline is intended to provide a jumping-off point for scientists, clinicians, and policymakers to assess the appropriateness of using ultrasound for diagnosis and treatment of central nervous system disorders.
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Mechanisms of Resistance to Macrolides and Lincosamides: Nature of the Resistance Elements and Their Clinical Implications
TL;DR: The results support the need for in vitro detection of macrolide resistance and correct interpretation of susceptibility tests to guide therapy and show that eradication of bacteria correlates with clinical outcome of acute otitis media in children.
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Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America
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Mechanisms of Multidrug Resistance in Acinetobacter Species and Pseudomonas aeruginosa
Robert A. Bonomo,Dóra Szabó +1 more
TL;DR: In addition, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance as discussed by the authors. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.
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Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship.
Rebecca R. Roberts,Bala Hota,Bala Hota,I. Ahmad,R. Douglas Scott,Susan Foster,Fauzia Abbasi,Shari Schabowski,Linda M. Kampe,Ginevra G. Ciavarella,Mark Supino,Jeremy Naples,Ralph L. Cordell,Stuart B. Levy,Robert A. Weinstein,Robert A. Weinstein +15 more
TL;DR: Data from this analysis could form the basis for a more comprehensive evaluation of the cost of resistance and the potential economic benefits of prevention programs.