Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more
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TLDR
A group of international experts came together through a joint initiative by the European Centre for Disease Prevention and Control and the Centers for Disease Control and Prevention, to create a standardized international terminology with which to describe acquired resistance profiles in Staphylococcus aureus, Enterococcus spp.About:
This article is published in Clinical Microbiology and Infection.The article was published on 2012-03-01 and is currently open access. It has received 8695 citations till now. The article focuses on the topics: Extensively drug resistant bacteria & Multiple drug resistance.read more
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Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide
Salvatore Piano,Virendra Singh,Paolo Caraceni,Rakhi Maiwall,Carlo Alessandria,Javier Romaní Fernández,Elza Cotrim Soares,Dong Joon Kim,Sung Eun Kim,M. Marino,Julio Vorobioff,Rita de Cassia Ribeiro Barea,Manuela Merli,Laure Elkrief,Victor Vargas,Aleksander Krag,Shivaram Prasad Singh,Laurentius A. Lesmana,C. Toledo,Sebastián Marciano,Xavier Verhelst,Florence Wong,Nicolas M. Intagliata,Liane Rabinowich,Luis Colombato,Sang Gyune Kim,Alexander L. Gerbes,François Durand,Juan Pablo Roblero,Kalyan Ram Bhamidimarri,Thomas D. Boyer,M. V. Maevskaya,Eduardo Fassio,Hyoung Su Kim,Jae Seok Hwang,Pere Ginès,Adrián Gadano,Shiv Kumar Sarin,Paolo Angeli,Michele Bartoletti,Carlos Brodersen,Tony Bruns,Robert A. de Man,Annette Dam Fialla,Carmine Gambino,Vikas Gautam,Marcos Girala,Adrià Juanola,Jeong Han Kim,Tae Hun Kim,Pramod Kumar,Barbara Lattanzi,Tae Hee Lee,Cosmas A. Rinaldi Lesmana,Richard Moreau,Preetam Nath,Gustavo Navarro,Ji Won Park,Gisela Pinero,Nikolaos Pyrsopoulos,Sophie Restellini,Gustavo Romero,Marco Sacco,Tiago Sevá-Pereira,Macarena Simón-Talero,Do Seon Song,Ki Tae Suk,Hans Van Vlierberghe,Sun Young Yim,E.L. Yoon,Giacomo Zaccherini +70 more
TL;DR: Differences in the prevalence of MDR bacterial infections in different global regions indicate the need for different empirical antibiotic strategies in different continents and countries.
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Relationship between Antibiotic Resistance, Biofilm Formation, and Biofilm-Specific Resistance in Acinetobacter baumannii
Lihua Qi,Hao Li,Chuanfu Zhang,Beibei Liang,Jie Li,Ligui Wang,Xinying Du,Xuelin Liu,Shaofu Qiu,Hongbin Song +9 more
TL;DR: Results from this study imply that biofilm acts as a mechanism for bacteria to get a better survival, especially in isolates with resistance level not high enough, as well as improving understanding of these processes and providing novel insights in the therapeutics and prevention against A. baumannii biofilm-related infections.
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Towards the sustainable discovery and development of new antibiotics
Marcus Miethke,Marco Pieroni,Tilmann Weber,Mark Brönstrup,Peter Hammann,Ludovic Halby,Paola B. Arimondo,Philippe Glaser,Bertrand Aigle,Helge B. Bode,Helge B. Bode,Rui Moreira,Yanyan Li,Andriy Luzhetskyy,Marnix H. Medema,Jean-Luc Pernodet,Marc Stadler,José R. Tormo,Olga Genilloud,Andrew W. Truman,Kira J. Weissman,Eriko Takano,Stefano Sabatini,Evi Stegmann,Heike Brötz-Oesterhelt,Wolfgang Wohlleben,Myriam Seemann,Martin Empting,Anna K. H. Hirsch,Brigitta Loretz,Claus-Michael Lehr,Alexander Titz,Jennifer Herrmann,Timo Jaeger,Silke Alt,Thomas Hesterkamp,Mathias Winterhalter,Andrea Schiefer,Kenneth Pfarr,Achim Hoerauf,Heather Graz,Michael Graz,Mika Lindvall,Savithri Ramurthy,Anders Karlén,Maarten van Dongen,Hrvoje Petković,Andreas Keller,Frédéric Peyrane,Stefano Donadio,Laurent Fraisse,Laura J. V. Piddock,Ian H. Gilbert,Heinz E. Moser,Rolf Müller +54 more
TL;DR: In this paper, the authors present a strategic blueprint to substantially improve our ability to discover and develop new antibiotics, and propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding.
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A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex.
Margaret M. C. Lam,Ryan R. Wick,Stephen C. Watts,Louise Cerdeira,Kelly L. Wyres,Kathryn E. Holt,Kathryn E. Holt +6 more
TL;DR: Kleborate as mentioned in this paper is a tool for analysing genomes of Klebsiella pneumoniae and its associated species complex, which consolidates interrogation of key features of proven clinical importance and provides a framework to support genomic surveillance and epidemiology in research, clinical and public health settings.
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Integrating rapid diagnostics and antimicrobial stewardship improves outcomes in patients with antibiotic- resistant Gram-negative bacteremia
Katherine K. Perez,Randall J. Olsen,William L. Musick,Patricia L. Cernoch,James R. Davis,Leif E. Peterson,James M. Musser +6 more
TL;DR: Integration of rapid identification and susceptibility techniques with antimicrobial stewardship resulted in significant improvements in clinical and financial outcomes for patients with bloodstream infections caused by antibiotic-resistant Gram-negatives.
References
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Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Helen W. Boucher,George H. Talbot,John S. Bradley,John S. Bradley,John E. Edwards,John E. Edwards,David N. Gilbert,Louis B. Rice,Louis B. Rice,Michael Scheld,Brad Spellberg,Brad Spellberg,John G. Bartlett +12 more
TL;DR: An update on potentially effective antibacterial drugs in the late-stage development pipeline is provided, in the hope of encouraging collaboration between industry, academia, the National Institutes of Health, the Food and Drug Administration, and the Centers for Disease Control and Prevention work productively together.
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Antimicrobial-Resistant Pathogens Associated with Healthcare- Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010
Dawn M. Sievert,Philip Ricks,Jonathan R. Edwards,Amy Schneider,Jean B. Patel,Arjun Srinivasan,Alex Kallen,Brandi Limbago,Scott K. Fridkin +8 more
TL;DR: The frequency of selected antimicrobial resistance patterns among pathogens causing device-associated and procedure-associated healthcare-associated infections reported by hospitals in the National Healthcare Safety Network (NHSN) is described.
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Comparison of mortality associated with methicillin-resistant and methicillin-susceptible staphylococcus aureus bacteremia: A meta-analysis
Sara E. Cosgrove,George Sakoulas,Eli N. Perencevich,Mitchell J. Schwaber,Adolf W. Karchmer,Yehuda Carmeli,Yehuda Carmeli +6 more
TL;DR: A meta-analysis was performed to summarize the impact of methicillin-resistance on mortality in Staphylococcus aureus bacteremia and explored the reasons for heterogeneity by means of subgroup analyses.
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Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern
TL;DR: More rapid diagnostic testing of ESBL-producing bacteria and the possible modification of guidelines for community-onset bacteraemia associated with UTIs are required.
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The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting
TL;DR: The data suggest that clinical efforts should be aimed at reducing the administration of inadequate antimicrobial treatment to hospitalized patients with bloodstream infections, especially individuals infected with antibiotic-resistant bacteria and Candida species.