Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
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Book ChapterDOI
Philosophical Issues in the Addictions
TL;DR: The final version of this paper is available from Cambridge University Press via the DOI in this record as mentioned in this paper and is available for download from the web site of this journal. But it is not available in print.
Book ChapterDOI
Neural Mechanisms Underlying Craving and the Regulation of Craving
Hedy Kober,Maggie Mae Mell +1 more
TL;DR: The role of the regulation of craving in reducing craving and in treatment for addiction, as well as the neural mechanisms that give rise to this ability are reviewed in this paper. But the role of these mechanisms is not discussed in this paper.
Journal ArticleDOI
The 5-HT2A Receptor (5-HT2AR) Regulates Impulsive Action and Cocaine Cue Reactivity in Male Sprague-Dawley Rats.
Dennis J. Sholler,Sonja J. Stutz,Robert G. Fox,Edward L. Boone,Qin Wang,Kenner C. Rice,F. Gerard Moeller,Noelle C. Anastasio,Kathryn A. Cunningham +8 more
TL;DR: Baseline levels of impulsive action predicted the effectiveness of pimavanserin to suppress incubated cue reactivity in late abstinence from cocaine self-administration at doses that were ineffective in early abstinence, and suggest that integration of clinical measures ofImpulsivity may inform refined, personalized pharmacotherapeutic intervention for the treatment of relapse vulnerability in CUD.
Journal ArticleDOI
Neural mechanisms underlying incubation of methamphetamine craving: A mini-review.
TL;DR: Mechanistic studies at the circuit, synaptic and molecular levels on incubation of Meth craving are reviewed and the translational potential of these mechanistic studies in Meth relapse prevention in human drug users is discussed.
References
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The Rat Brain in Stereotaxic Coordinates
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
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Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
Journal ArticleDOI
The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.