Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
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DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale
Deborah S. Hasin,Charles P. O'Brien,Marc Auriacombe,Guilherme Borges,Kathleen K. Bucholz,Alan J. Budney,Wilson M. Compton,Thomas J. Crowley,Walter Ling,Nancy M. Petry,Marc A. Schuckit,Bridget F. Grant +11 more
TL;DR: The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, and moving gambling disorders to the chapter formerly reserved for substance-related disorders.
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Transcriptional and epigenetic mechanisms of addiction
TL;DR: Multiple mechanisms by which drugs alter the transcriptional potential of genes are reviewed, including alterations in the accessibility of genes within their native chromatin structure induced by histone tail modifications and DNA methylation, and the regulation of gene expression by non-coding RNAs.
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Liking, wanting, and the incentive-sensitization theory of addiction.
TL;DR: The incentive-sensitization theory posits the essence of drug addiction to be excessive amplification specifically of psychological "wanting," especially triggered by cues, without necessarily an amplification of "liking."
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Opiate versus psychostimulant addiction: the differences do matter
TL;DR: It is argued that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
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The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
TL;DR: The ventral subiculum and lateral hypothalamus are highlighted as emerging brain areas important for reinstatement of drug seeking across drug classes and the existence of differences in brain mechanisms controlling reinstatement in drug seeking is highlighted.
References
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Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin.
Jennifer M. Bossert,Anna L. Stern,Florence R. M. Theberge,Carlo Cifani,Eisuke Koya,Bruce T. Hope,Yavin Shaham +6 more
TL;DR: In a rat model of context-induced relapse to heroin, a small subset of ventral mPFC neurons formed neuronal ensembles that encode the learned associations between heroin reward and heroin-associated contexts; re-activation of these neurons by drug- associated contexts during abstinence provoked drug relapse.
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AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine
TL;DR: It is proposed that AMPAR transmission is enhanced, resulting in stronger responding to drug-paired cues after prolonged withdrawal in the absence of extinction training, which may contribute to a broad range of addiction-related behavioral changes.
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Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats
TL;DR: The duration of the heroin withdrawal period is an important factor in the manifestation of footshock stress-induced reinstatement of heroin seeking and extinction of theHeroin-reinforced behavior.
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Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications.
TL;DR: This review provides an update on several novel candidate medications for relapse prevention suggested by recent preclinical studies, and discusses the translation of findings from nonhuman laboratory studies to the clinical phenomenon of relapse.
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Neurotrophic factors and structural plasticity in addiction.
TL;DR: Recent advances in understanding of how brain-derived neurotrophic factor and its signaling pathways regulate structural and behavioral plasticity in the context of drug addiction are discussed.