Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
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DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale
Deborah S. Hasin,Charles P. O'Brien,Marc Auriacombe,Guilherme Borges,Kathleen K. Bucholz,Alan J. Budney,Wilson M. Compton,Thomas J. Crowley,Walter Ling,Nancy M. Petry,Marc A. Schuckit,Bridget F. Grant +11 more
TL;DR: The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, and moving gambling disorders to the chapter formerly reserved for substance-related disorders.
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Transcriptional and epigenetic mechanisms of addiction
TL;DR: Multiple mechanisms by which drugs alter the transcriptional potential of genes are reviewed, including alterations in the accessibility of genes within their native chromatin structure induced by histone tail modifications and DNA methylation, and the regulation of gene expression by non-coding RNAs.
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Liking, wanting, and the incentive-sensitization theory of addiction.
TL;DR: The incentive-sensitization theory posits the essence of drug addiction to be excessive amplification specifically of psychological "wanting," especially triggered by cues, without necessarily an amplification of "liking."
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Opiate versus psychostimulant addiction: the differences do matter
TL;DR: It is argued that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
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The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
TL;DR: The ventral subiculum and lateral hypothalamus are highlighted as emerging brain areas important for reinstatement of drug seeking across drug classes and the existence of differences in brain mechanisms controlling reinstatement in drug seeking is highlighted.
References
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State-dependent Ras signaling and AMPA receptor trafficking
Yi Qin,Yinghua Zhu,Joel P. Baumgart,Ruth L. Stornetta,Kenneth Seidenman,Volker Mack,Linda Van Aelst,J. Julius Zhu +7 more
TL;DR: It is shown that state-dependent Ras signaling, which specifies downstream MEK-ERK and Pi3K-PKB pathways, differentially control GluR2L- and GLUR1-dependent synaptic plasticity.
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Cocaine seeking over extended withdrawal periods in rats: different time courses of responding induced by cocaine cues versus cocaine priming over the first 6 months.
TL;DR: Results indicate that the withdrawal period is a critical modulator of drug seeking provoked by re-exposure to cocaine cues, but not cocaine itself, and that while the incubation of responsiveness to cocaine cue is a long lasting phenomenon, it is not permanent.
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Cocaine-Associated Stimuli Increase Cocaine Seeking and Activate Accumbens Core Neurons after Abstinence
TL;DR: The results reflect a cellular neuroadaptation in the Acb core related to cocaine-associated cues that is observed during initial cue exposure and sustained during extinction and resumption of self-administration after prolonged drug abstinence.
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Central amygdala extracellular signal-regulated kinase signaling pathway is critical to incubation of opiate craving.
TL;DR: It is found that the rat's response to environmental cues previously paired with morphine progressively increases or incubates over the first 14 d of withdrawal from low but not high morphine doses, which is mediated by acute activation of central amygdala ERK pathway.
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Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats.
TL;DR: The data suggest that the withdrawal period can modulate reward seeking of both drug and non-drug reinforcers, and that alterations in DAT and TH levels in the brain regions examined do not mediate this effect.