Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
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Role of nucleus accumbens core but not shell in incubation of methamphetamine craving after voluntary abstinence
Ludovica Maddalena Rossi,Ingrid Reverte,Davide Ragozzino,Aldo Badiani,Aldo Badiani,Marco Venniro,Daniele Caprioli +6 more
TL;DR: It is suggested that dopamine transmission through Drd1 and Drd2 in NAc core is critical to the incubation of methamphetamine craving after voluntary abstinence.
Journal ArticleDOI
Response of the Ubiquitin-Proteasome System to Memory Retrieval After Extended-Access Cocaine or Saline Self-Administration.
TL;DR: It is suggested that the relationship between UPS activity and memory retrieval depends on training paradigm, brain region, and time elapsed between training and retrieval, and effects of cocaine memory retrieval on proteasome activity, relative to saline memory retrieval, depend on withdrawal time.
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Repeated restraint stress exposure during early withdrawal accelerates incubation of cue-induced cocaine craving
Ryan Glynn,J. Amiel Rosenkranz,Marina E. Wolf,Aaron Caccamise,Freya Shroff,Alyssa B. Smith,Jessica A. Loweth +6 more
TL;DR: It is indicated that chronic stress exposure enhances the initial rate of incubation of craving during early withdrawal, resulting in increased vulnerability to cue‐induced relapse during this period, and may lead to a persistent increase in vulnerability to the relapse‐promoting effects of stress.
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Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model.
TL;DR: It is indicated that the timing of exercise availability differentially impacts cocaine seeking with results suggesting that exercise during early, but not late, abstinence may provide long-term protection against cocaine relapse.
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Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala.
TL;DR: The findings demonstrate that TIP39 signaling within the MeA at the time of an aversive event regulates the increase over time in fear associated with the event context, which will help in the understanding of why traumatic events sometimes have severe psychological consequences.
References
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
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Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
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The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.