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Open AccessJournal ArticleDOI

Neurobiology of the incubation of drug craving

TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.
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This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.

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Journal ArticleDOI

Acute food deprivation-induced relapse to heroin seeking after short and long punishment-imposed abstinence in male rats

TL;DR: Results suggest that stress is a reliable trigger to relapse even after a prolonged period of punishment-induced, voluntary abstinence, and exposure to food-deprivation stress induced a robust relapse to heroin seeking after short and long punishment-imposed abstinence periods.
Book ChapterDOI

Targeting Opioid Receptors for Innovative Antidepressant Therapies: Rediscovering the Opioid Cure

TL;DR: Future studies will address all three opioid receptor functions in emerging neurobiological aspects of depression, including neurogenesis, neurodevelopment, and social behaviors.
Book ChapterDOI

Abstinence-Conflict Model: Toward an Optimal Animal Model for Screening Medications Promoting Drug Abstinence.

TL;DR: It is argued that the use of animal abstinence/relapse models that more closely approximate human drug addiction could lead to a better understanding of the neurobiological and environmental factors that support long-term drug abstinence, which will lead to the development of more effective environmental and pharmacotherapeutic interventions to treat opiate addiction and addiction to other drugs of abuse.
References
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Book

The Rat Brain in Stereotaxic Coordinates

TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
Journal ArticleDOI

Neurotrophins as synaptic modulators

TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
Journal ArticleDOI

The GDNF family: Signalling, biological functions and therapeutic value

TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.
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