Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
More filters
Journal ArticleDOI
Possible involvement of chemokine ligands in addictive drugs-induced conditioned place preference in mice
Journal ArticleDOI
Acute food deprivation-induced relapse to heroin seeking after short and long punishment-imposed abstinence in male rats
TL;DR: Results suggest that stress is a reliable trigger to relapse even after a prolonged period of punishment-induced, voluntary abstinence, and exposure to food-deprivation stress induced a robust relapse to heroin seeking after short and long punishment-imposed abstinence periods.
Book ChapterDOI
Targeting Opioid Receptors for Innovative Antidepressant Therapies: Rediscovering the Opioid Cure
TL;DR: Future studies will address all three opioid receptor functions in emerging neurobiological aspects of depression, including neurogenesis, neurodevelopment, and social behaviors.
Book ChapterDOI
Abstinence-Conflict Model: Toward an Optimal Animal Model for Screening Medications Promoting Drug Abstinence.
TL;DR: It is argued that the use of animal abstinence/relapse models that more closely approximate human drug addiction could lead to a better understanding of the neurobiological and environmental factors that support long-term drug abstinence, which will lead to the development of more effective environmental and pharmacotherapeutic interventions to treat opiate addiction and addiction to other drugs of abuse.
Journal ArticleDOI
Persistence of Drug Memories: Melting Transcriptomes.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
Journal ArticleDOI
Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
Journal ArticleDOI
The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.