Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
More filters
Journal ArticleDOI
The Winding Road to Relapse: Forging a New Understanding of Cue-Induced Reinstatement Models and Their Associated Neural Mechanisms.
TL;DR: This review will discuss how models of drug addiction and relapse should more systematically evaluate different types of stimuli to better understand the neurobiology underlying craving and relapse and how behavioral and pharmacotherapeutic interventions may be better tailored to promote drug use cessation outcomes and long-term abstinence.
Journal ArticleDOI
Incubation of extinction responding and cue-induced reinstatement, but not context- or drug priming-induced reinstatement, after withdrawal from methamphetamine.
Sweta Adhikary,Daniele Caprioli,Marco Venniro,Paige Kallenberger,Yavin Shaham,Jennifer M. Bossert +5 more
TL;DR: Together, incubation of methamphetamine craving, as assessed in extinction tests, is primarily mediated by time‐dependent increases in non‐reinforced operant responding, and this effect is potentiated by exposure to discrete, but not contextual, cues.
Journal ArticleDOI
Investigation of the neuroanatomical substrates of reward seeking following protracted abstinence in mice
TL;DR: While some brain regions were implicated in both drug and food seeking, other specific parts of the brain were activated for either sucrose or morphine relapse, which supports existing literature regarding relapse‐like behaviour in rats.
Journal ArticleDOI
Biological substrates of addiction.
TL;DR: This review is an introduction to addiction, the reward circuitry, and laboratory addiction models and shows how altered function of a wide variety of brain regions is tightly associated with specific manifestations of drug abuse.
Journal ArticleDOI
Risk preferences impose a hidden distortion on measures of choice impulsivity.
TL;DR: A model is advanced which, when applied to standard choice tasks typically used in psychology and neuroscience, provides both a better fit to the data and successfully de-correlates risk and impulsivity parameters, which results in measures that are more accurate and thus of greater utility to the many fields interested in individual differences in impulsivity.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
Journal ArticleDOI
Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
Journal ArticleDOI
The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.