Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
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Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future.
TL;DR: A comprehensive picture of the current status of what is known about the endocannabinoid system mechanisms that underlie modification of brain-reward processes is provided to provide the development of potential pharmacotherapies designed to treat reward-dysfunction-related disorders.
Journal ArticleDOI
Animal Models of (or for) Aggression Reward, Addiction, and Relapse: Behavior and Circuits.
TL;DR: The pharmacological and circuit mechanisms of aggression conditioned place preference and aggression self-administration, seeking, and relapse are discussed, highlighting mechanistic congruence and divergence between appetitive and consummatory phases of aggression.
Journal ArticleDOI
Different Roles of BDNF in Nucleus Accumbens Core versus Shell during the Incubation of Cue-Induced Cocaine Craving and Its Long-Term Maintenance
Xuan Li,M. R. DeJoseph,Janice H. Urban,Amine Bahi,Jean-Luc Dreyer,Gloria E. Meredith,Kerstin A. Ford,Carrie R. Ferrario,Jessica A. Loweth,Marina E. Wolf +9 more
TL;DR: BDNF protein levels in the NAc were significantly increased after ampakine treatment, supporting the novel hypothesis that the gradual increase of BDNF levels in NAc accompanying incubation could be caused by increased AMPAR transmission during withdrawal.
Journal ArticleDOI
Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation.
Argel Aguilar-Valles,Thomas Vaissière,Erica M. Griggs,Mikael A. Mikaelsson,Irma F. Takács,Erica J. Young,Gavin Rumbaugh,Courtney A. Miller +7 more
TL;DR: In this paper, the role of the associated epigenetic modifiers in METH-associated memory was investigated, and the development and expression of METHassociated memory were supported by regulation of H3K4me2/3 levels by MLL1 and KDM5c, respectively, in the NAc.
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Different Adaptations in AMPA Receptor Transmission in the Nucleus Accumbens after Short vs Long Access Cocaine Self-Administration Regimens
Anthony Purgianto,Andrew F. Scheyer,Jessica A. Loweth,Kerstin A. Ford,Kuei Y. Tseng,Marina E. Wolf +5 more
TL;DR: Results show that CP-AMPAR accumulation and enhanced glutamate transmission is associated with longer sessions (6 h), rather than the number of sessions or cocaine infusions, and are associated with increased baseline responsiveness of MSN to excitatory drive.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
Journal ArticleDOI
Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
Journal ArticleDOI
The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.