Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
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DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale
Deborah S. Hasin,Charles P. O'Brien,Marc Auriacombe,Guilherme Borges,Kathleen K. Bucholz,Alan J. Budney,Wilson M. Compton,Thomas J. Crowley,Walter Ling,Nancy M. Petry,Marc A. Schuckit,Bridget F. Grant +11 more
TL;DR: The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, and moving gambling disorders to the chapter formerly reserved for substance-related disorders.
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Transcriptional and epigenetic mechanisms of addiction
TL;DR: Multiple mechanisms by which drugs alter the transcriptional potential of genes are reviewed, including alterations in the accessibility of genes within their native chromatin structure induced by histone tail modifications and DNA methylation, and the regulation of gene expression by non-coding RNAs.
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Liking, wanting, and the incentive-sensitization theory of addiction.
TL;DR: The incentive-sensitization theory posits the essence of drug addiction to be excessive amplification specifically of psychological "wanting," especially triggered by cues, without necessarily an amplification of "liking."
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Opiate versus psychostimulant addiction: the differences do matter
TL;DR: It is argued that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
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The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
TL;DR: The ventral subiculum and lateral hypothalamus are highlighted as emerging brain areas important for reinstatement of drug seeking across drug classes and the existence of differences in brain mechanisms controlling reinstatement in drug seeking is highlighted.
References
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Brain circuitry and the reinstatement of cocaine-seeking behavior.
TL;DR: The proposed convergence of priming stimuli into the glutamatergic projection from anterior cingulate to the accumbens core combined with the changes in glutamate transmission and signaling that accompany repeated psychostimulant administration points to the potential value of pharmacological agents that manipulate glutamate release or postsynaptic glutamate receptor signaling and trafficking in treating primed relapse in addicts.
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Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving
TL;DR: Time-dependent increases in BDNF levels may lead to synaptic modifications that underlie enhanced responsiveness to cocaine cues after prolonged withdrawal periods, and these changes were observed during tests for sucrose craving.
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The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats.
Rita A. Fuchs,K. Allison Evans,Christopher C Ledford,Macon P. Parker,Jordan M. Case,Ritu H. Mehta,Ronald E. See +6 more
TL;DR: D dorsal hippocampus, basolateral amygdala, and dorsomedial prefrontal cortex play critical roles in contextual reinstatement of cocaine-seeking behavior and the involvement of the DH in explicit CS- and cocaine-induced reinstatement is investigated.
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Classical conditioning in drug-dependent humans.
TL;DR: Clinical studies have been instituted to determine whether modification of conditioned responses can influence clinical outcome, and a recently completed study in cocaine addicts has produced evidence that outcome can be improved by a passive extinction technique over an 8-week outpatient treatment program.
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Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction.
TL;DR: It is suggested that protracted exposure to addictive drugs recruits serial and dopamine-dependent, striato-nigro-striatal ascending spirals from the nucleus accumbens to more dorsal regions of the striatum that underlie a shift from action-outcome to stimulus-response mechanisms in the control over drug seeking.