Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
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Journal ArticleDOI
Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence.
Daniele Caprioli,Marco Venniro,Michelle Zhang,Jennifer M. Bossert,Brandon L. Warren,Bruce T. Hope,Yavin Shaham +6 more
TL;DR: In this article, the role of dorsolateral striatum and dorsomedial striatum (DMS) in the incubation of methamphetamine craving after choice-based voluntary abstinence was investigated.
Journal ArticleDOI
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking
Ashley E. Lepack,Craig T. Werner,Andrew F. Stewart,Sasha L. Fulton,Ping Zhong,Lorna A. Farrelly,Alexander C.W. Smith,Aarthi Ramakrishnan,Yang Lyu,Ryan M. Bastle,Jennifer A. Martin,Swarup Mitra,Richard M. O'Connor,Zi-Jun Wang,Henrik Molina,Gustavo Turecki,Li Shen,Zhen Yan,Erin S. Calipari,David M. Dietz,Paul J. Kenny,Ian Maze +21 more
TL;DR: By reducing H3Q5dop in the VTA during withdrawal, this work reversed cocaine-mediated gene expression changes, attenuated dopamine release in the nucleus accumbens, and reduced cocaine-seeking behavior, establishing a neurotransmission-independent role for nuclear dopamine in relapse-related transcriptional plasticity in the rat ventral tegmental area.
Journal ArticleDOI
Co-occurrence of alcohol use disorder and behavioral addictions: relevance of impulsivity and craving
Marco Di Nicola,Daniela Tedeschi,Luisa De Risio,Mauro Pettorruso,Giovanni Martinotti,F. Ruggeri,Kevin Swierkosz-Lenart,Riccardo Guglielmo,Antonino Callea,Giuseppe Ruggeri,Gino Pozzi,Massimo Di Giannantonio,Luigi Janiri +12 more
TL;DR: High levels of impulsivity and craving for alcohol seem to be associated with other addictive behaviors, and a significant rate of co-occurrence of BAs in AUD is emphasized.
Journal ArticleDOI
Incubation of Methamphetamine Craving Is Associated with Selective Increases in Expression of Bdnf and Trkb, Glutamate Receptors, and Epigenetic Enzymes in Cue-Activated Fos-Expressing Dorsal Striatal Neurons
Xuan Li,F. Javier Rubio,Tamara Zeric,Jennifer M. Bossert,Sarita Kambhampati,Hannah M. Cates,Pamela J. Kennedy,Qing-Rong Liu,Raffaello Cimbro,Bruce T. Hope,Eric J. Nestler,Yavin Shaham +11 more
TL;DR: Results demonstrate a critical role of DS in incubation of methamphetamine craving and that this incubation is associated with selective gene-expression alterations in cue-activated D1- and D2-expressing DS neurons.
Journal ArticleDOI
Corticostriatal BDNF and alcohol addiction.
TL;DR: Evidence is provided that moderate consumption of alcohol increases BDNF levels in the dorsal striatum, which in turn act to suppress alcohol intake by activating a Mitogen-Activated Protein Kinase (MAPK)-dependent genomic mechanism.
References
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