Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
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DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale
Deborah S. Hasin,Charles P. O'Brien,Marc Auriacombe,Guilherme Borges,Kathleen K. Bucholz,Alan J. Budney,Wilson M. Compton,Thomas J. Crowley,Walter Ling,Nancy M. Petry,Marc A. Schuckit,Bridget F. Grant +11 more
TL;DR: The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, and moving gambling disorders to the chapter formerly reserved for substance-related disorders.
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Transcriptional and epigenetic mechanisms of addiction
TL;DR: Multiple mechanisms by which drugs alter the transcriptional potential of genes are reviewed, including alterations in the accessibility of genes within their native chromatin structure induced by histone tail modifications and DNA methylation, and the regulation of gene expression by non-coding RNAs.
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Liking, wanting, and the incentive-sensitization theory of addiction.
TL;DR: The incentive-sensitization theory posits the essence of drug addiction to be excessive amplification specifically of psychological "wanting," especially triggered by cues, without necessarily an amplification of "liking."
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Opiate versus psychostimulant addiction: the differences do matter
TL;DR: It is argued that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
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The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
TL;DR: The ventral subiculum and lateral hypothalamus are highlighted as emerging brain areas important for reinstatement of drug seeking across drug classes and the existence of differences in brain mechanisms controlling reinstatement in drug seeking is highlighted.
References
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TL;DR: The results provide a laboratory demonstration of cocaine-induced increases in the urge to use drugs in humans and suggest the possibility of distinguishing among related, but perhaps distinct, components of the fluctuating levels of motivation to reuse drugs.
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Disrupting Reconsolidation of Drug Memories Reduces Cocaine-Seeking Behavior
TL;DR: It is demonstrated that appetitive CS-drug memories undergo reconsolidation in a manner similar to aversive memories and that this amygdala-dependent reconsolidations can be disrupted to reduce the impact of drug cues on drug seeking.
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ERK2: a logical AND gate critical for drug-induced plasticity?
Jean-Antoine Girault,Emmanuel Valjent,Emmanuel Valjent,Jocelyne Caboche,Jocelyne Caboche,Denis Hervé,Denis Hervé +6 more
TL;DR: It is suggested that the ERK2 pathway acts as a logical AND gate, permissive for plasticity, in neurons on which dopamine-mediated reward signals and glutamate-mediated contextual information converge.
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Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
Manuel Mameli,Briac Halbout,Cyril Creton,David Engblom,Jan Rodriguez Parkitna,Rainer Spanagel,Christian Lüscher,Christian Lüscher +7 more
TL;DR: Overriding mGluR1 in vivo led to synaptic plasticity in the NAc, which contributes to cocaine-seeking behavior after protracted withdrawal and could represent a first step in the recruitment of the neuronal network that underlies drug addiction.
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Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-activated protein kinase pathway.
TL;DR: Results demonstrate that dendritic, A-type K+ channels are dually regulated by PKA and PKC through a common downstream pathway involving MAPK, and the modulation of these K+channels may be accounted for by the phosphorylation of Kv4.2 subunits.