Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
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Role of Central Amygdala Neuronal Ensembles in Incubation of Nicotine Craving.
TL;DR: It is demonstrated that incubation of nicotine craving occurs after adolescent-onset nicotine self-administration and that neuronal ensembles in the central nucleus of the amygdala play a critical role in this incubation in adult rats.
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Olfactory Aversive Conditioning during Sleep Reduces Cigarette-Smoking Behavior
TL;DR: A single night of olfactory aversive conditioning during sleep significantly reduced cigarette-smoking behavior in a sleep stage-dependent manner, and this effect persisted for several days.
Journal ArticleDOI
Compulsive addiction-like aggressive behavior in mice
Sam A. Golden,Conor Heins,Marco Venniro,Daniele Caprioli,Michelle Zhang,David H. Epstein,Yavin Shaham +6 more
TL;DR: Using procedures established to model drug addiction, it is shown that a subpopulation of CD-1 mice demonstrate "addiction-like" aggressive behavior, suggesting an evolutionary origin for compulsive aggression.
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The Role of Adenosine Receptors in Psychostimulant Addiction.
TL;DR: Different experimental data support the hypothesis that A2A/D2 heterodimers are partly responsible for the psychomotor and reinforcing effects of psychostimulant drugs, such as cocaine and amphetamine, and the stimulation of A 2A receptor is proposed as a potential therapeutic target for the treatment of drug addiction.
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Recent updates on incubation of drug craving: a mini-review
TL;DR: A mini‐review of three excellent Addiction Biology publications on incubation of drug craving in both human and laboratory animals and several key publications from the past year on behavioral and mechanistic findings related to incubated drug craving.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
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Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
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The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.