Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
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Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system
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Exercise during Abstinence Normalizes Ultrastructural Synaptic Plasticity Associated with Nicotine-Seeking following Extended Access Self-Administration.
Victoria Sanchez,Anousheh Bakhti-Suroosh,Andrew N Chen,Darlene H. Brunzell,Alev Erisir,Wendy J. Lynch +5 more
TL;DR: Findings indicate an association between nicotine‐seeking and synaptic plasticity in the nucleus accumbens, particularly the core, and indicate that the efficacy of exercise to reduce nicotine‐ seeking may be mediated by reversing these adaptations.
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microRNA expression levels in the nucleus accumbens correlate with morphine‐taking but not morphine‐seeking behaviour in male rats
TL;DR: It is demonstrated that 30 days of forced abstinence results in a time‐dependent increase in morphine seeking in a rat model of morphine self‐administration (SA), and lasting regulation of miRNA expression is associated with drug intake following morphine SA, indicating that the miRNA profile undergoes regulation from early to late abstinence and miRNAs expression may indicate past drug history.
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REM Sleep Engages MCH Neurons to Reduce Cocaine Seeking
Rong Guo,Yao Q. Wang,Rongzhen Yan,Bo Chen,Wanqiao Ding,Michael T. Gorczyca,Sahin Ozsoy,Li Cai,Rachel Hines,George C. Tseng,Giancarlo Allocca,Yan Dong,Jidong Fang,Yanhua H. Huang +13 more
TL;DR: In this paper , the authors examined the correlations between the intensity of cue-induced cocaine seeking and key sleep features, and found that rapid eye movement sleep (REMS) may encode individual vulnerability to relapse, and MCH neuron activities can be selectively targeted during REMS to reduce drug relapse.
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Pre-quit nicotine decreases nicotine self-administration and attenuates cue- and drug-induced reinstatement
TL;DR: It is suggested that administration of a nicotine replacement prior to a nominated quit date may enhance resistance to relapse via disruption of the contingency between a response, its associated cues, and a rewarding nicotine effect.
References
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Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
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Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.