Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
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DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale
Deborah S. Hasin,Charles P. O'Brien,Marc Auriacombe,Guilherme Borges,Kathleen K. Bucholz,Alan J. Budney,Wilson M. Compton,Thomas J. Crowley,Walter Ling,Nancy M. Petry,Marc A. Schuckit,Bridget F. Grant +11 more
TL;DR: The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, and moving gambling disorders to the chapter formerly reserved for substance-related disorders.
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Transcriptional and epigenetic mechanisms of addiction
TL;DR: Multiple mechanisms by which drugs alter the transcriptional potential of genes are reviewed, including alterations in the accessibility of genes within their native chromatin structure induced by histone tail modifications and DNA methylation, and the regulation of gene expression by non-coding RNAs.
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Liking, wanting, and the incentive-sensitization theory of addiction.
TL;DR: The incentive-sensitization theory posits the essence of drug addiction to be excessive amplification specifically of psychological "wanting," especially triggered by cues, without necessarily an amplification of "liking."
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Opiate versus psychostimulant addiction: the differences do matter
TL;DR: It is argued that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
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The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
TL;DR: The ventral subiculum and lateral hypothalamus are highlighted as emerging brain areas important for reinstatement of drug seeking across drug classes and the existence of differences in brain mechanisms controlling reinstatement in drug seeking is highlighted.
References
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Journal ArticleDOI
Neuroadaptation. Incubation of cocaine craving after withdrawal.
TL;DR: Behavioural evidence is provided from laboratory animals suggesting that the onset of craving is delayed and that craving does not decay, but rather increases progressively, over a two-month withdrawal period.
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Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review
TL;DR: The main conclusion of this review is that the neuronal mechanisms involved in relapse to heroin and cocaine seeking induced by drug priming, drug cues, and stressors are to a large degree dissociable.
Journal ArticleDOI
Functional receptor for GDNF encoded by the c-ret proto-oncogene.
Miles Trupp,Ernest Arenas,Mike Fainzilber,Ann-Sofie Nilsson,Beth-Anne Sieber,Maria Grigoriou,Carol Kilkenny,Edgar F. Salazar-Grueso,Vassilis Pachnis,Urmas Arumäe,Hannu Sariola,Mart Saarma,Carlos F. Ibáñez +12 more
TL;DR: It is shown that GDNF binds to, and induces tyrosine phosphorylation of, the product of the c-ret proto-oncogene, an orphan receptor tyrosin kinase, in a GDNF responsive motor-neuron cell line, which encodes a functional receptor for GDNF that may mediate its neurotrophic effects on motor and dopaminergic neurons.
Journal ArticleDOI
Relapse rates in addiction programs
Book
The Amygdala: a functional analysis
TL;DR: Functional neuroimaging of the amygdala during emotional processing and learning shows the importance of fibres of passage from the basal forebrain in the memory of reward.