Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
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Role of orbitofrontal cortex in incubation of oxycodone craving in male rats.
Rachel D. Altshuler,Eddy S. Yang,Kristine T. Garcia,Ian R. Davis,Adedayo Olaniran,Meron Haile,Syrus Razavi,Xuan Li +7 more
TL;DR: Results here show that OFC plays a critical role in incubation of opioid craving, and lever presses during relapse tests were higher on withdrawals day 15 than on withdrawal day 1 (incubation of oxycodone craving).
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AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking
Xue-Jiao Gao,Kai Yuan,Kai Yuan,Lu Cao,Wei Yan,Yi-Xiao Luo,Min Jian,Jian-Feng Liu,Qin Fang,Ji-Shi Wang,Ying Han,Jie Shi,Lin Lu,Lin Lu +13 more
TL;DR: Results indicate that AMPK activity in the NAc core is critical for the cue-induced reinstatement of cocaine seeking, which may be mediated by mTORC1 and ERK1/2 signaling.
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Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence
Craig T. Werner,Swarup Mitra,Benjamin D. Auerbach,Zi-Jun Wang,Jennifer A. Martin,Andrew F. Stewart,Pedro H. Gobira,Pedro H. Gobira,Madoka Iida,Chunna An,Moriah M. Cobb,Moriah M. Cobb,Aaron Caccamise,Richard Salvi,Rachael L. Neve,Amy M. Gancarz,David M. Dietz +16 more
TL;DR: A role for the dorsal hippocampus is demonstrated in relapse behavior following prolonged abstinence from cocaine self-administration and synaptic strength in the DH is examined during prolonged abstinence and an increase in moderate long-term potentiation in cocaine-treated rats compared to saline controls is observed.
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One month of cocaine abstinence potentiates rapid dopamine signaling in the nucleus accumbens core.
TL;DR: One month of cocaine abstinence potentiates the peak concentration of electrically evoked DA in the NAc core following an acute injection of cocaine, which further support the abundance of literature showing that cocaine abstinence induces neuroplasticity in brain areas implicated in drug reward and relapse.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
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Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
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The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.