Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
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Journal ArticleDOI
Epigenetics and addiction.
TL;DR: A better understanding of epigenetic mechanisms in animal models that mimic human conditions should help to usher in a new area of drug development against addiction.
Journal ArticleDOI
Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins
Victória A Müller Ewald,Benjamin J. De Corte,Subhash C. Gupta,Katherine V. Lillis,Nandakumar S. Narayanan,John A. Wemmie,Ryan T. LaLumiere +6 more
TL;DR: Results suggest the utility of an SSFO-based approach for enhancing activity in a structure without driving specific patterns of neuronal firing and suggest that the ability of the IL to reduce cocaine seeking depends, at least in part, on rats first having undergone extinction training.
Journal ArticleDOI
A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype.
TL;DR: The results suggest that the role of glutamatergic signaling in the NAc, though not essential for motivating cocaine use in nonaddicted stages, becomes critical once addiction has developed.
Journal ArticleDOI
The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder
Xiaoli Liu,Xiwen Zhao,Ting Liu,Qingming Liu,Qingming Liu,Li Tang,Hui Zhang,Wenbo Luo,Zafiris J. Daskalakis,Ti-Fei Yuan,Ti-Fei Yuan +10 more
TL;DR: The results suggest that rTMS applied to the DLPFC is effective in reducing craving severity in heroin use disorder patients and suggest that such treatment effects can last for up to 60 days after treatment cessation.
Book ChapterDOI
Memory Reconsolidation: Lingering Consolidation and the Dynamic Memory Trace
TL;DR: It is proposed that memory reconsolidation contributes to a lingering consolidation process and that memory is a highly dynamic process and new therapies for weakening maladaptive memories and enhancing memories to combat cognitive decline are proposed.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
TL;DR: It is hypothesized that the change from voluntary drug use to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug seeking and drug taking behavior as well as a progression from ventral to more dorsal domains of the striatum, involving its dopaminergic innervation.
Journal ArticleDOI
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
Journal ArticleDOI
Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
Journal ArticleDOI
The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.