Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
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State dependent effect of transcranial direct current stimulation (tDCS) on methamphetamine craving
Alireza Shahbabaie,Mehrshad Golesorkhi,Behnam Zamanian,Mitra Ebrahimpoor,Fatemeh Keshvari,Vahid Nejati,Felipe Fregni,Hamed Ekhtiari +7 more
TL;DR: While active prefrontal tDCS acutely reduced craving at rest in the abstinent meth users, it increased craving during meth-related cue exposure, reflecting the important role of the prefrontal cortex in both cue saliency evaluation and urge to meth consumption.
Journal ArticleDOI
Incubation of Methamphetamine but not Heroin Craving After Voluntary Abstinence in Male and Female Rats.
TL;DR: The results show that incubation of methamphetamine craving after voluntary abstinence generalizes to female rats, and prolonged voluntary abstinence prevented the emergence of incubating of heroin craving in both sexes.
Journal ArticleDOI
Serotonin at the Nexus of Impulsivity and Cue Reactivity in Cocaine Addiction
TL;DR: The role of 5-HT and its receptor proteins in key addiction phenotypes and the implications of current findings to the future of therapeutics in addiction are emphasized.
Journal ArticleDOI
Effect of Chronic Delivery of the Toll-like Receptor 4 Antagonist (+)-Naltrexone on Incubation of Heroin Craving
Florence R. M. Theberge,Xuan Li,Sarita Kambhampati,Charles L. Pickens,Robyn St. Laurent,Jennifer M. Bossert,Michael H. Baumann,Mark R. Hutchinson,Kenner C. Rice,Linda R. Watkins,Yavin Shaham +10 more
TL;DR: A critical role of TLR4 is suggested in the development of incubation of heroin, but not methamphetamine, craving and chronic delivery of (+)-naltrexone via minipumps during the withdrawal phase decreased incubated cue-induced heroin seeking.
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Relapse to opioid seeking in rat models: behavior, pharmacology and circuits
TL;DR: Pharmacological and circuit mechanisms of opioid seeking, as assessed in the classical extinction-reinstatement model, are discussed, including the phenomenon of “incubation of heroin craving” (the time-dependent increases in heroin seeking during abstinence).
References
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The Rat Brain in Stereotaxic Coordinates
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
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TL;DR: In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake and did not increase total neuron or astrocyte numbers or transmitter uptake.
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Neurotrophins as synaptic modulators
TL;DR: By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections.
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The GDNF family: Signalling, biological functions and therapeutic value
Matti S. Airaksinen,Mart Saarma +1 more
TL;DR: Members of the nerve growth factor and glial cell line-derived neurotrophic factor families — comprising neurotrophins and GDNF-family ligands (GFLs) — are crucial for the development and maintenance of distinct sets of central and peripheral neurons.