Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TLDR
Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.About:
This article is published in Trends in Neurosciences.The article was published on 2011-08-01 and is currently open access. It has received 550 citations till now. The article focuses on the topics: Craving & Methamphetamine.read more
Citations
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DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale
Deborah S. Hasin,Charles P. O'Brien,Marc Auriacombe,Guilherme Borges,Kathleen K. Bucholz,Alan J. Budney,Wilson M. Compton,Thomas J. Crowley,Walter Ling,Nancy M. Petry,Marc A. Schuckit,Bridget F. Grant +11 more
TL;DR: The work group recommendations for DSM-5 revisions included combining abuse and dependence criteria into a single substance use disorder based on consistent findings from over 200,000 study participants, dropping legal problems and adding craving as criteria, and moving gambling disorders to the chapter formerly reserved for substance-related disorders.
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Transcriptional and epigenetic mechanisms of addiction
TL;DR: Multiple mechanisms by which drugs alter the transcriptional potential of genes are reviewed, including alterations in the accessibility of genes within their native chromatin structure induced by histone tail modifications and DNA methylation, and the regulation of gene expression by non-coding RNAs.
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Liking, wanting, and the incentive-sensitization theory of addiction.
TL;DR: The incentive-sensitization theory posits the essence of drug addiction to be excessive amplification specifically of psychological "wanting," especially triggered by cues, without necessarily an amplification of "liking."
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Opiate versus psychostimulant addiction: the differences do matter
TL;DR: It is argued that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
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The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
TL;DR: The ventral subiculum and lateral hypothalamus are highlighted as emerging brain areas important for reinstatement of drug seeking across drug classes and the existence of differences in brain mechanisms controlling reinstatement in drug seeking is highlighted.
References
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Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats.
TL;DR: Cocaine self‐administration produces long‐lasting molecular neuroadaptations in the VTA and accumbens that may underlie cocaine relapse during periods of abstinence.
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Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.
David Engblom,Ainhoa Bilbao,Carles Sanchis-Segura,Lionel Dahan,Stephanie Perreau-Lenz,Bénédicte Balland,Jan Rodriguez Parkitna,Rafael Luján,Briac Halbout,Manuel Mameli,Rosanna Parlato,Rolf Sprengel,Christian Lüscher,Christian Lüscher,Günther Schütz,Rainer Spanagel +15 more
TL;DR: It is reported that in midbrain slices of cocaine-treated mice, synaptic transmission was no longer strengthened when GluR1 or NR1 was abolished, while in the respective mice the drug still induced normal conditioned place preference and locomotor sensitization.
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Role of ventral medial prefrontal cortex in incubation of cocaine craving.
Eisuke Koya,Jamie L. Uejima,Kristina A. Wihbey,Jennifer M. Bossert,Bruce T. Hope,Yavin Shaham +5 more
TL;DR: The present results indicate that ventral mPFC neuronal activity plays an important role in the incubation of cocaine craving.
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Neural substrates of cocaine-cue associations that trigger relapse.
TL;DR: Results reveal the importance of the amygdala in the acquisition, consolidation, and expression of drug-stimulus learning that drives relapse to drug-seeking behavior.
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Incubation of Cue-Induced Cigarette Craving During Abstinence in Human Smokers
Gillinder Bedi,Gillinder Bedi,Kenzie L. Preston,David H. Epstein,Stephen J. Heishman,Gina F. Marrone,Yavin Shaham,Harriet de Wit +7 more
TL;DR: Initial evidence of incubation of cue-induced craving in humans is presented, with the observation that cue- induced craving increases with abstinence, even as "background" craving and withdrawal symptoms subside, might have treatment implications.